Michael T. Lee

Jeffrey W Sall3
Greg Stratmann3
Ban Ku2
Joseph S Bell2
3Jeffrey W Sall
3Greg Stratmann
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  • Greg Stratmann, Jeffrey W Sall, Laura D V May, Joseph S Bell, Kathy R Magnusson, Vinuta Rau +5 others
  • 2009
BACKGROUND Anesthetic agents cause cell death in the developing rodent brain and long-term, mostly hippocampal-dependent, neurocognitive dysfunction. However, a causal link between these findings has not been shown. Postnatal hippocampal neurogenesis affects hippocampal function into adulthood; therefore, the authors tested the hypothesis that isoflurane(More)
  • Greg Stratmann, Jeffrey W Sall, Joseph S Bell, Rehan S Alvi, Laura d V May, Ban Ku +7 others
  • 2010
BACKGROUND Roughly, 10% of elderly patients develop postoperative cognitive dysfunction. General anesthesia impairs spatial memory in aged rats, but the mechanism is not known. Hippocampal neurogenesis affects spatial learning and memory in rats, and isoflurane affects neurogenesis in neonatal and young adult rats. We tested the hypothesis that isoflurane(More)
Anesthetic drugs cause brain cell death and long-term neurocognitive dysfunction in neonatal rats. Recently, human data also suggest that anesthesia early in life may cause cognitive impairment. The connection between cell death and neurocognitive decline is uncertain. It is conceivable that mechanisms other than brain cell death contribute to(More)
TREK-1, an outward-rectifying potassium channel activated by stretch, is found in the myometrium of pregnant women. Decreased expression of TREK-1 near term suggests that TREK-1 may contribute to uterine quiescence during gestation. Five alternatively spliced TREK-1 variants were identified in the myometrium of mothers who delivered spontaneously preterm(More)
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