Michael Stehle

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Separase, an endopeptidase required for the separation of sister-chromatides in mitotic anaphase, triggers centriole disengagement during centrosome duplication. In cancer, separase is frequently overexpressed, pointing to a functional role as an aneuploidy promoter associated with centrosomal amplification and genomic instability. Recently, we have shown(More)
The abundance stratification in the ejecta of the normal Type Ia Supernova 2002bo is derived fitting a series of spectra obtained at close time intervals. A Montecarlo code, modified to include abundance stratification, is used to compute synthetic spectra at 13 epochs in the photospheric phase, starting 13 days before B maximum. A description of the(More)
Extensive light and colour curves for the Type Ia supernova SN 2002er are presented as part of the European Supernova Collaboration. We have collected U BV RI photometry from ten different telescopes covering the phases from 7 days before until 619 days after maximum light. Corrections for the different instrumental systems and the non-thermal spectrum of(More)
Genomic instability and clonal evolution are hallmarks of progressing chronic myeloid leukemia (CML). Recently, we have shown that clonal evolution and blast crisis correlate with altered expression and activity of Separase, a cysteine endopeptidase that is a mitotic key player in chromosomal segregation and centriole duplication. Hyperactivation of(More)
The spectral properties of type Ia supernovae in the ultraviolet (UV) are investigated with the early-time spectra of SN 2001ep and SN 2001eh obtained using the Hubble Space Telescope (HST). A series of spectral models is computed with a Monte Carlo spectral synthesis code, and the dependence of the UV flux on the elemental abundances and the density(More)
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