Learn More
The clinical efficacy of a systemically administered drug acting on the central nervous system depends on its ability to pass the blood-brain barrier, which is regulated by transporter molecules such as ABCB1 (MDR1). Here we report that polymorphisms in the ABCB1 gene predict the response to antidepressant treatment in those depressed patients receiving(More)
Major depression (MD) is one of the most prevalent psychiatric disorders and a leading cause of loss in work productivity. A combination of genetic and environmental risk factors probably contributes to MD. We present data from a genome-wide association study revealing a neuron-specific neutral amino acid transporter (SLC6A15) as a susceptibility gene for(More)
—Several standardization efforts for Smart Grids in US and Europe are currently gaining momentum. Even if there are different focuses in US and Europe on what is known as the smart grid, all agree on the fact, that standardization is a key issue for a proper technical interoperability [4]. Hence, a lot of studies and roadmaps pick standardization in the(More)
Biogeochemical elemental cycling is driven by primary production of biomass via phototrophic phytoplankton growth, with 40% of marine productivity being assigned to diatoms. Phytoplankton growth is widely limited by the availability of iron, an essential component of the photosynthetic apparatus. The oceanic diatom Thalassiosira oceanica shows a remarkable(More)
Galanin (GAL) is an estrogen-inducible neuropeptide, highly expressed in brain regions reported to be involved in regulation of mood and anxiety. GAL possibly has a direct modulatory effect on hypothalamic-pituitary-adrenal (HPA)-axis regulation. Recent data from pharmacological and genetic studies indicate a significant function of GAL in stress-related(More)
MOTIVATION Assembling the relevant information needed to interpret the output from high-throughput, genome scale, experiments such as gene expression microarrays is challenging. Analysis reveals genes that show statistically significant changes in expression levels, but more information is needed to determine their biological relevance. The challenge is to(More)
Glutamate decarboxylase (GAD) is the rate limiting enzyme for conversion of glutamic acid to gamma-aminobutyric acid (GABA). The GAD 65 kDa isoform is encoded by the gene GAD2 and is mainly expressed in synaptic terminals. It serves as an apoenzyme, which shows enhanced availability in situations of stress, responding to short-term demands for GABA. We(More)
In this paper we present concepts for integrating glyphs into volumetric data sets. These concepts have been developed with the goal to make glyph-based visualization of multimodal volumetric data sets more flexible and intuitive. We propose a surface-based glyph placement strategy reducing visual clutter as well as image-space glyph aggre-gation. Thus the(More)
—The IEC 61970/61968 Common Information Model is undoubtedly one of the core standards of the future smart grid as pointed out by different organizations and recent standardization roadmaps. Its acceptance in the energy sector and the active standardization work is very high and make it one of the most established standards worldwide in the energy domain.(More)