Michael Song

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XTENs are unstructured, nonrepetitive protein polymers designed to prolong the in vivo half-life of pharmaceuticals by introducing a bulking effect similar to that of poly(ethylene glycol). While XTEN can be expressed as a recombinant fusion protein with bioactive proteins and peptides, therapeutic molecules of interest can also be chemically conjugated to(More)
Firms' organizational structures impose constraints on their ability to use promotion-based incentives. We develop a framework for identifying these constraints and exploring their consequences. We show that …rms manage workers careers by choosing personnel policies that resemble an internal labor market. Firms may adopt forced-turnover policies to keep(More)
Background Cell line generation (CLG) in the scope of bioproduc-tion can be defined as a method to isolate a single cell expressing a recombinant protein of interest. The standard method of CLG often involves the introduction of the transgene into a cell in an attempt to use the cellular machinery for transcription, translation and secretion. The use of(More)