Michael Silbermann

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The main objective of this research was to study the relationship between glucocorticoids, aging and the deterioration of cognitive functions. Towards this end, an attempt was made to develop an animal model which will enable the investigation of such interactions, using subcutaneously implanted sustained-release corticosterone pellets. The goal was to(More)
Age-related histopathological changes in the hippocampal formation were correlated with cognitive performance, evaluated in rats at the 8-arm radial maze. Experiments were conducted using young (3 months), mature (12 months), middle-aged (17 months) and aged (24 months) Wistar rats. Significant memory impairments were already observed at the age of 12(More)
Obstructive sleep apnea (OSA) is a common disorder of the middle aged and elderly. It results from the decrease in upper airway muscle (UAM) tone that occurs during sleep. It is unclear whether age-related changes in UAM could constitute a contributory mechanism to the increased prevalence of OSA with increasing age, and previous papers evaluating the(More)
Cognitive and memory capacities were assessed in two strains of rats of various age groups prior to histological evaluation of their brains. Male Wistar rats, at the age of 3, 12, 17 and 24 months, were tested using the 8-arm radial maze and male Fischer 344 rats, aged 3, 12 and 16 months, were tested in the Morris water maze. Significant memory impairments(More)
BACKGROUND Asthma is a complex genetic disease with more than 20 genome-wide scans conducted so far. Regions on almost every chromosome have been linked to asthma and several genes have been associated. However, most of these associations are weak and are still awaiting replication. METHODS In this study, we conducted a second-stage genome-wide scan with(More)
An ultrastructural evaluation was made of the changes encountered in the motor endplates of the gastrocnemius muscle of old mice in comparison with young-adult mice. In old, 27-month-old mice, a great variety of changes were recorded. The main abnormalities occurred in the axon terminals, the myoneural junctional folds, and the endomysial space. Loss of(More)
In order to study the possible etiologic role of lead in human motor neuron disease we produced chronic lead intoxication in the chicken by daily administration of lead acetate. Control animals received sodium acetate. During life, periodic measurements were made of motor function, motor nerve conduction velocity and response amplitude. After sacrifice,(More)
Cognitive performance in aging Wistar rats was monitored using the radial arm maze and the latter was correlated with the density of muscarinic receptors in the CNS, using quantitative in vitro receptor autoradiography. Significant working memory deficits were observed in 12, 17 and 24-month-old rats as compared to 3-month-old animals. In addition, the(More)
C57BL/6J mice (6, 19 and 27 months old) were trained in an electrically driven treadmill for a total period of 10 weeks. The training program started with 5 min. run per day and reached a maximum of 30 min. per day. Light and electron microscopy examinations of the gastrocnemius muscle showed that in young animals endurance training did not evoke any(More)
Histomorphometric analysis of age-related structural changes in the brain was performed in CW1 female mice, 3, 9, 24 and 32 months of age. Cholinergic regions, such as the hippocampus, NBM and the medial habenula (MH) were investigated in more detail focusing on morphological parameters. The thickness of the frontoparietal cortex (FPC), and the surface area(More)