Michael Seeger

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A vast amount of bioinformatics information is continuously being introduced to different databases around the world. Handling the various applications used to study this information present a major data management and analysis challenge to researchers. The present work investigates the problem of integrating heterogeneous applications and databases towards(More)
It has been suggested that degradation of polyubiquitylated proteins is coupled to dissociation of 26S proteasomes. In contrast, using several independent types of experiments, we find that mammalian proteasomes can degrade polyubiquitylated proteins without disassembling. Thus, immobilized, (35)S-labeled 26S proteasomes degraded polyubiquitylated Sic1 and(More)
Fuzzy based models have been used in many areas of research. One issue with these models is that rule bases have the potential for indiscriminant growth. Inference systems with large number of rules can be overspecified, have model comprehension issues and suffer from bad performance. In this research we investigate the use of a genetic algorithm towards(More)
BACKGROUND Genome characterization of the model PCB-degrading bacterium Burkholderia xenovorans LB400 revealed the presence of eleven central pathways for aromatic compounds degradation, among them, the homogentisate and the homoprotocatechuate pathways. However, the functionality of these central pathways in strain LB400 has not been assessed and related(More)
This paper describes the development of an inference system used for the identification of genes that encode enzymes of metabolic pathways. Input sequence alignment values are used to classify the best candidate genes for inclusion in a metabolic pathway map. The system workflow allows the user to provide feedback, which is stored in conjunction with(More)
Copper mining has led to Cu pollution in agricultural soils. In this report, the effects of Cu pollution on bacterial communities of agricultural soils from Valparaiso region, central Chile, were studied. Denaturing gradient gel electrophoresis (DGGE) of the 16S rRNA genes was used for the characterization of bacterial communities from Cu-polluted and(More)
BACKGROUND Mercury-polluted environments are often contaminated with other heavy metals. Therefore, bacteria with resistance to several heavy metals may be useful for bioremediation. Cupriavidus metallidurans CH34 is a model heavy metal-resistant bacterium, but possesses a low resistance to mercury compounds. METHODOLOGY/PRINCIPAL FINDINGS To improve(More)
  • Verónica Morgante, Arantxa López-López, Cecilia Flores, Myriam González, Bernardo González, Mónica Vásquez +2 others
  • 2010
Bioremediation is an important technology for the removal of persistent organic pollutants from the environment. Bioaugmentation with the encapsulated Pseudomonas sp. strain MHP41 of agricultural soils contaminated with the herbicide simazine was studied. The experiments were performed in microcosm trials using two soils: soil that had never been previously(More)
The human genome encodes several ubiquitin-like (UBL) domain proteins (UDPs). Members of this protein family are involved in a variety of cellular functions and many are connected to the ubiquitin proteasome system, an essential pathway for protein degradation in eukaryotic cells. Despite their structural similarity, the UBL domains appear to have a range(More)