Michael Sean Wiesener

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.

Peter Maxwell, Michael Sean Wiesener, +7 authors Peter J Ratcliffe
Nature
1999

Hypoxia-inducible factor-1 (HIF-1) has a key role in cellular responses to hypoxia, including the regulation of genes involved in energy metabolism, angiogenesis and apoptosis. The alpha subunits of… (More)

Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly…

Christina Warnecke, Zaneta Zaborowska, +4 authors K. - U. Eckardt
FASEB journal : official publication of the…
2004

Activation of the hypoxia-inducible factor alpha-subunits, HIF-1alpha and HIF-2alpha, seems to be subject to similar regulatory mechanisms, and transgene approaches suggested partial functional… (More)

Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.

Michael Sean Wiesener, H. Turley, +9 authors Peter Maxwell
Blood
1998

Hypoxia results in adaptive changes in the transcription of a range of genes including erythropoietin. An important mediator is hypoxia-inducible factor-1 (HIF-1), a DNA binding complex shown to… (More)

Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function.

Jonathan Jantsch, Dipshikha Chakravortty, +11 authors Carsten Willam
Journal of immunology
2008

Dendritic cells (DC) play a key role in linking innate and adaptive immunity. In inflamed tissues, where DC become activated, oxygen tensions are usually low. Although hypoxia is increasingly… (More)

Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene…

S. M. Wood, Michael Sean Wiesener, +4 authors Peter J Ratcliffe
The Journal of biological chemistry
1998

Hypoxia-inducible expression has been demonstrated for many groups of mammalian genes, and studies of transcriptional control have revealed the existence of hypoxia-responsive elements (HREs) in the… (More)

Tumor suppressor activity and epigenetic inactivation of hepatocyte growth factor activator inhibitor type 2/SPINT2 in papillary and clear cell renal cell carcinoma.

Mark R. Morris, Dean Gentle, +9 authors Eamonn R Maher
Cancer research
2005

Following treatment with a demethylating agent, 5 of 11 renal cell carcinoma (RCC) cell lines showed increased expression of hepatocyte growth factor (HGF) activator inhibitor type 2… (More)

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia.

Koen Brusselmans, Veerle Compernolle, +4 authors Peter Carmeliet
The Journal of clinical investigation
2003

Chronic hypoxia induces pulmonary vascular remodeling, leading to pulmonary hypertension, right ventricular hypertrophy, and heart failure. Heterozygous deficiency of hypoxia-inducible factor-1alpha… (More)

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

Michael Sean Wiesener, Jan Steffen Juergensen, +11 authors K. - U. Eckardt
FASEB journal : official publication of the…
2003

Cellular responses to oxygen are increasingly recognized as critical in normal development and physiology, and are implicated in pathological processes. Many of these responses are mediated by the… (More)

Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1.

Tina Gimm, Melanie Wiese, +10 authors Christina Warnecke
FASEB journal : official publication of the…
2010

Hypoxia-inducible protein 2 (HIG2) has been implicated in canonical Wnt signaling, both as target and activator. The potential link between hypoxia and an oncogenic signaling pathway might play a… (More)

Autosomal dominant tubulointerstitial kidney disease: diagnosis, classification, and management--A KDIGO consensus report.

K. - U. Eckardt, Seth L Alper, +10 authors Olivier Devuyst
Kidney international
2015

Rare autosomal dominant tubulointerstitial kidney disease is caused by mutations in the genes encoding uromodulin (UMOD), hepatocyte nuclear factor-1β (HNF1B), renin (REN), and mucin-1 (MUC1).… (More)

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