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BACKGROUND Remote ischaemic preconditioning attenuates cardiac injury at elective surgery and angioplasty. We tested the hypothesis that remote ischaemic conditioning during evolving ST-elevation myocardial infarction, and done before primary percutaneous coronary intervention, increases myocardial salvage. METHODS 333 consecutive adult patients with a(More)
BACKGROUND An accurate, noninvasive technique for the diagnosis of coronary disease would be an important advance. We investigated the accuracy of coronary magnetic resonance angiography among patients with suspected coronary disease in a prospective, multicenter study. METHODS Coronary magnetic resonance angiography was performed during free breathing in(More)
BACKGROUND We have demonstrated that myocardial acceleration during isovolumic contraction (IVA) is a sensitive index of left ventricular contractile function. In this study, we assessed the utility of IVA to measure right ventricular (RV) contractile function. METHODS AND RESULTS We examined 8 pigs by using tissue Doppler imaging of the RV free wall and(More)
BACKGROUND Remote ischemic preconditioning (RIPC) induced by transient limb ischemia releases a dialysable circulating protective factor that reduces ischemia-reperfusion injury. Exercise performance in highly trained athletes is limited by tissue hypoxemia and acidosis, which may therefore represent a type of ischemia-reperfusion stress modifiable by RIPC.(More)
BACKGROUND We have demonstrated that myocardial acceleration during isovolumic contraction (IVA) is a sensitive index of right ventricular contractile function. In this study, we assessed the usefulness of IVA to measure left ventricular (LV) contractile function and force-frequency relationships in an experimental preparation. METHODS AND RESULTS In(More)
Recombinant adeno-associated virus (rAAV) is a promising vector for gene therapy. Recent isolations of novel AAV serotypes have led to significant advances by broadening the tropism and increasing the efficiency of gene transfer to the desired target cell. However, a major concern that remains is the strong preexisting immune responses to several vectors.(More)
In many applications, like indexing of broadcast news or surveillance applications, the input data consists of a continuous, unseg-mented audio stream. Speech recognition technology, however, usually requires segments of relatively short length as input. For such applications, effective methods to segment continuous audio streams into homogeneous segments(More)
BACKGROUND/AIMS Nucleic acid testing (NAT) for hepatitis B virus (HBV) DNA in blood donations identified occult HBV infection (OBI) as a potential threat to blood safety. METHODS A collaborative study was undertaken to explore the molecular basis of OBIs prevalent in Europe in relation to clinical and serological data. RESULTS Ninety-one percent of 77(More)
In laser microstructuring there is a general conflict between precision and efficiency. Short pulsed micro-and nanosecond systems generally allow high ablation rates. Yet, thermal damage of the workpiece cannot be avoided completely. Ultrafast pico-and femtosecond systems allow a higher precision, yet at lower ablation efficiency. This on the one hand can(More)