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Motivated by the ongoing success of Linked Data and the growing amount of semantic data sources available on the Web, new challenges to query processing are emerging. Especially in distributed settings that require joining data provided by multiple sources, sophisticated optimization techniques are necessary for efficient query processing. We propose novel(More)
In this paper we present FedBench, a comprehensive benchmark suite for testing and analyzing the performance of federated query processing strategies on semantic data. The major challenge lies in the heterogeneity of semantic data use cases, where applications may face different settings at both the data and query level, such as varying data access(More)
Recently, the SPARQL query language for RDF has reached the W3C recommendation status. In response to this emerging standard, the database community is currently exploring efficient storage techniques for RDF data and evaluation strategies for SPARQL queries. A meaningful analysis and comparison of these approaches necessitates a comprehensive and universal(More)
We study the termination problem of the chase algorithm, a central tool in various database problems such as the constraint implication problem, Conjunctive Query optimization, rewriting queries using views, data exchange, and data integration. The basic idea of the chase is, given a database instance and a set of constraints as input, to fix constraint(More)
Recombinant adeno-associated virus (rAAV) is a promising vector for gene therapy. Recent isolations of novel AAV serotypes have led to significant advances by broadening the tropism and increasing the efficiency of gene transfer to the desired target cell. However, a major concern that remains is the strong preexisting immune responses to several vectors.(More)
Gene therapy vectors based on adeno-associated viruses (AAVs) show promise for the treatment of retinal degenerative diseases. In prior work, subretinal injections of AAV2, AAV5, and AAV2 pseudotyped with AAV5 capsids (AAV2/5) showed variable retinal pigmented epithelium (RPE) and photoreceptor cell transduction, while AAV2/1 predominantly transduced the(More)
We study fundamental aspects related to the efficient processing of the SPARQL query language for RDF, proposed by the W3C to encode machine-readable information in the Semantic Web. Our key contributions are (i) a complete complexity analysis for all operator fragments of the SPARQL query language, which -- as a central result -- shows that the SPARQL(More)
Adeno-associated viruses (AAVs) depend on a helper virus for efficient replication. To identify novel AAV isolates, we screened a diverse set of virus isolates for the presence of AAV DNA. AAVs found in 10 simian adenovirus isolates showed greater than 96% homology to AAV1 and AAV6 but had distinct biological properties. Two representatives of this group,(More)
Gene transfer using adeno-associated viruses (AAVs) has been effective for treating inherited retinal diseases in animal models. Further evaluation in primates must be performed prior to clinical application, however, because of the difference between the retina of the primate and those of other animals. Prior work has shown that AAV2 can transduce(More)
In response to acute damage, Müller glia in the chicken retina have been shown to be a source of proliferating progenitor-like cells. The secreted factors and signaling pathways that regulate this process remain unknown. The purpose of this study was to test whether secreted factors, which are known to promote glial differentiation during development,(More)