Michael Scheid

Learn More
Mutations in the PTEN-induced kinase 1 (PINK1) gene have recently been implicated in autosomal recessive early onset Parkinson Disease (1, 2). To investigate the role of PINK1 in neurodegeneration, we designed human and murine neuronal cell lines expressing either wild-type PINK1 or PINK1 bearing a mutation associated with Parkinson Disease. We show that(More)
Lungenembolien unterschiedlicher Ätiologie und Pathogenese sind auch heute noch gravierende Krankheitsbilder. Wir berichten über einen Fall von Lungenembolie, bei dem die initial atypische Symptomatik und zunächst negative Befunde den Therapiebeginn verzögerten. Die herzchirurgische Therapie fand nach Notfallverlegung des im kardiogenen Schock befindlichen(More)
Neoaortic root dilatation can develop during long-term follow-up after an arterial switch operation (ASO). Although few patients require surgical reintervention, significant valve regurgitation is still an important cause of late morbidity. We report on a 15-year-old boy with significant dilatation of the neoaortic root that was treated with the(More)
Ein Horner-Syndrom (einseitige Miosis, Ptosis, Enophthalmus) wird durch eine Irritation bzw. Schädigung des Ganglion stellatum ausgelöst. Im vorliegenden Fall kam es nach Resektion einer Aortenisthmusstenose und Anlage einer linksseitigen Thoraxdrainage am 3. postoperativen Tag zur Ausbildung eines Horner-Syndroms. Thoraxdrainagen sind als sehr seltene(More)
Nedocromil is a new non-bronchodilator substance with mast cell stabilizing properties. In an acute placebo-controlled randomized double blind study, the protective effect of nedocromil on the bronchoconstrictor action of nebulised hypo-(distilled water) and hyperosmolar (4% saline) solutions was investigated in 12 patients with allergic asthma. Inhalations(More)
Dry cough is one of the most common side-effects of angiotensin converting enzyme inhibitors. The mechanism of cough induced by ACE inhibitors is not completely understood and may be related to bronchial hyperreactivity and/or an accumulation of kinins. In a placebo-controlled, double-blind randomised study, the effect of captopril on lung function and(More)
BACKGROUND A plethora of valves and valve conduits are available for reconstruction of the right ventricular outflow tract (RVOT) for grown-up congenital heart patients. However, for several reasons, the ideal pulmonary valve substitute still remains the subject of debate. In this study, we investigated the preliminary clinical and echocardiographic results(More)
Einleitung Die aktuelle Diskussion um betriebliche Anwendungsarchitekturen ist inWissenschaft und Praxis durch das Paradigmader serviceorientiertenArchitektur (SOA) geprägt [6, 11, 18, 24, 34, 38, 51]. Durch SOA soll es möglich werden, Anwendungssysteme flexibel aus eigenständigen Softwarefunktionen (Services) zusammenstellen zukönnen.DieAnwendungen sollen(More)
Transcatheter aortic valve implantation (TAVI) represents a therapeutic option of increasing impact for the treatment of high-risk patients with symptomatic, severe aortic valve stenosis. We report here the case of an 86-year old patient with a cutaneo-pericardial fistula after a transapical TAVI procedure.