Michael S. von Bergwelt-Baildon

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Due to proliferation and increased metabolism, cancer cells have high glucose requirements. The glucose uptake of cells is influenced by a group of membrane proteins denoted the glucose transporter family (Glut-1 to -12). Whereas increased expression and a negative correlation with survival have been described for Glut-1 in several types of cancer, the(More)
Immune tolerance is a central mechanism counteracting tumor-specific immunity and preventing effective anticancer immunotherapy. Induction of tolerance requires a specific environment in which tolerogenic dendritic cells (DCs) play an essential role deviating the immune response away from effective immunity. It was recently shown that maturation of DCs in(More)
Die febrile Neutropenie ist weiterhin einer der häufigsten Gründe für die stationäre Aufnahme von Patienten mit hämatoonkologischer Grunderkrankung. Diese Patienten haben ein bis zu 10-fach erhöhtes Risiko, eine Sepsis und andere schwere Komplikationen zu erleiden, die wiederum häufig zur Verlegung auf eine Intensivstation führen. Aktuelle Untersuchungen(More)
Chronic lymphocytic leukemia (CLL) is characterized by a distinct chemoresistance, which is thought to be caused by microenvironmental stimulation. In particular, the pivotal role of environmental survival cues involving signaling downstream to CD40 or B-cell receptor in CLL survival and chemoresponse is well characterized. In contrast, despite its evident(More)
Allogeneic stem cell transplantation is a treatment option for patients with poor risk CLL. We conducted a retrospective analysis of all CLL patients allografted at our institution, the University Hospital of Cologne, Germany. Data was collected on 40 patients from 2004 to 2012. The mean age was 54, and the majority were male (75 %). On average, the(More)
Das klinische Management von Infektionen während einer Neutropenie stellt eine große diagnostische und therapeutische Herausforderung dar. Die etablierten Sepsiskriterien sind nur bedingt anwendbar. Die Diagnostik wird durch eine begleitende Thrombopenie und die häufige respiratorische Insuffizienz erschwert. Fulminante Verläufe, eine Blutungsneigung und(More)
Although accumulating evidence strongly suggests that aplastic anemia (AA) is a T cell–mediated autoimmune disease, no target antigens have yet been described for AA. In autoimmune diseases, target autoantigens frequently induce not only cellular T-cell responses but also humoral B-cell responses. We hypothesized that the presence of antigen-specific(More)
1 Grimwade D, Walker H, Oliver F, Wheatley K, Harrison C, Harrison G et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children’s Leukaemia Working Parties. Blood 1998; 92: 2322–2333. 2 Dash A, Gilliland DG. Molecular genetics of acute(More)
Primary cutaneous lymphomas (PCLs) are clonal Tor B-cell neoplasms, which originate in the skin. In recent years, mast cells were described as regulators of the tumor microenvironment in different human malignancies. Here, we investigated the role of mast cells in the tumor microenvironment of PCL. We found significantly increased numbers of mast cells in(More)
The recovery of the host immune system after allogeneic hematopoietic stem cell transplantation is pivotal to prevent infections, relapse, and secondary malignancies. In particular, numerical CD4+ T cells reconstitution is delayed and CD4 helper cell function is considered impaired as a consequence of the transplant procedure and concomitant(More)