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  • Michael S Wolfe, Weiming Xia, Beth L. Ostaszewski, Thekla S. Diehl, W. Taylor Kimberly, Dennis J Selkoe
  • Medicine, Biology
  • Nature
  • 1999 (First Publication: 1 April 1999)
  • Accumulation of the amyloid-β protein (Aβ) in the cerebral cortex is an early and invariant event in the pathogenesis of Alzheimer's disease. The final step in the generation of Aβ from the β-amyloidExpand
  • W. Taylor Kimberly, Matthew J Lavoie, Beth L. Ostaszewski, Wenjuan Ye, Michael S Wolfe, Dennis J Selkoe
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2003 (First Publication: 9 May 2003)
  • γ-Secretase catalyzes the intramembrane proteolysis of Notch, β-amyloid precursor protein, and other substrates as part of a new signaling paradigm and as a key step in the pathogenesis ofExpand