RATIONALE AND OBJECTIVES To investigate the frequency and radiographic patterns of tumoral cavitation in patients with non-small cell lung cancer (NSCLC) treated with bevacizumab, and correlate the imaging findings with the pathology, clinical characteristics and outcome. MATERIALS AND METHODS Seventy-two patients with NSCLC treated with bevacizumab… (More)
INTRODUCTION There are few effective treatment options for leptomeningeal metastasis (LM) in non-small-cell lung cancer (NSCLC). This study assessed the feasibility of high-dose gefitinib in patients with LM from NSCLC harboring EGFR mutations or prior systemic response to EGFR-TKI. METHODS This phase I open-label trial of a novel gefitinib dosing… (More)
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