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As part of our effort in developing a spoken language system for interactive problem solving, we recently collected a sizeable amount of speech data. This database is composed of spontaneous sentences which were collected during a simulated human/machine dialogue. Since a computer log of the spoken dialogue was maintained, we were able to ask the subjects(More)
PURPOSE Anthracycline-induced cardiotoxicity (ACT) is a serious adverse drug reaction limiting anthracycline use and causing substantial morbidity and mortality. Our aim was to identify genetic variants associated with ACT in patients treated for childhood cancer. PATIENTS AND METHODS We carried out a study of 2,977 single-nucleotide polymorphisms (SNPs)(More)
Cisplatin is a widely used and effective chemotherapeutic agent, although its use is restricted by the high incidence of irreversible ototoxicity associated with it. In children, cisplatin ototoxicity is a serious and pervasive problem, affecting more than 60% of those receiving cisplatin and compromising language and cognitive development. Candidate gene(More)
Recently, we initiated a project to develop a phonetically-based spoken language understanding system called SUMMIT. In contrast to many of the past efforts that make use of heuristic rules whose development requires intense knowledge engineering, our approach attempts to express the speech knowledge within a formal framework using well-defined mathematical(More)
This paper represents a status report on the MIT ATIS system. The most significant new achievement is that we now have a speech-input mode. It is based on the MIT SUMMIT system using context independent phone models, and includes a word-pair grammar with perplexity 92 (on the June-90 test set). In addition , we have completely redesigned the back-end(More)
BACKGROUND Familial history is a strong risk factor for coronary artery disease (CAD), especially for early-onset myocardial infarction (MI). Several genes and chromosomal regions have been implicated in the genetic cause of coronary artery disease/MI, mostly through the discovery of familial mutations implicated in hyper-/hypocholesterolemia by linkage(More)
BACKGROUND ABO and D phenotyping of both blood donors and patients receiving transfusions is routinely performed by blood banks to ensure compatibility. These analyses are performed by antibody-based agglutination assays. Blood is not tested for minor blood group antigens on a regular basis, however, because of cost and time constraints. This can result in(More)