Learn More
Over the last decade, the introduction of microarray technology has had a profound impact on gene expression research. The publication of studies with dissimilar or altogether contradictory results, obtained using different microarray platforms to analyze identical RNA samples, has raised concerns about the reliability of this technology. The MicroArray(More)
External RNA controls (ERCs), although important for microarray assay performance assessment, have yet to be fully implemented in the research community. As part of the MicroArray Quality Control (MAQC) study, two types of ERCs were implemented and evaluated; one was added to the total RNA in the samples before amplification and labeling; the other was(More)
BACKGROUND Point of care access to electronic medical records may provide clinicians with the information they want when they need it and may in turn improve patient safety. Yet providing an electronic medical record on handheld devices presents many usability challenges, and it is unclear whether clinicians will use them. METHODS An iterative design(More)
OBJECTIVE To review the available evidence evaluating the toxicological profiles of electronic cigarettes (e-cigarettes) in order to understand the potential impact of e-cigarettes on individual users and the public health. METHODS Systematic literature searches were conducted between October 2012 and October 2013 using five electronic databases. Search(More)
OBJECTIVE To identify and evaluate the effectiveness, clinical usefulness, sustainability, and usability of web-compatible diabetes-related tools. DATA SOURCES Medline, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, world wide web. STUDY SELECTION Studies were included if they described an electronic audiovisual tool used as a means to(More)
Diseases and death caused by exposure to tobacco smoke have become the single most serious preventable public health concern. Thus, biomarkers that can monitor tobacco exposure and health effects can play a critical role in tobacco product regulation and public health policy. Biomarkers of exposure to tobacco toxicants are well established and have been(More)
The Family Smoking Prevention and Tobacco Control Act of 2009 (Public Law 111-31) gave the US Food and Drug Administration (FDA) the responsibility for regulating tobacco products. Nicotine is the primary addictive component of tobacco and its effects can be modulated by additional ingredients in manufactured products. Nicotine acts by mimicking the(More)
OBJECTIVE To investigate whether there is any significant difference between the electronic and the paper-based version of Urogenital Distress Inventory-6 questionnaire (UDI-6) and the Incontinence Impact Questionnaire-7 questionnaire (IIQ-7). MATERIALS AND METHODS An electronic questionnaire and clinical tool was developed using a combination of open(More)
Toxicogenomics has evolved into a useful technique for providing greater mechanistic insights into adverse effects that will spur the development of novel approaches for identifying and understanding toxicity issues. The ability to capture a snapshot of the transcriptome at any given time during the development of an adverse phenotype allows unprecedented(More)
In the MCF-7 breast iunior cell line, induction of bulk damage to DNA (measured either as total strand breaks or as double-strand breaks I fails to correspond » ¡Hi the antiprciliferative activity of the demethylepipodo-phyllotoxin derivative, VM-26. In contrast, VM-26 produces an early (within 2-3 h) concentration-dependent reduction in e-myc expression(More)