Michael S. Orr

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OBJECTIVE To identify and evaluate the effectiveness, clinical usefulness, sustainability, and usability of web-compatible diabetes-related tools. DATA SOURCES Medline, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, world wide web. STUDY SELECTION Studies were included if they described an electronic audiovisual tool used as a means to(More)
OBJECTIVE To review the available evidence evaluating the toxicological profiles of electronic cigarettes (e-cigarettes) in order to understand the potential impact of e-cigarettes on individual users and the public health. METHODS Systematic literature searches were conducted between October 2012 and October 2013 using five electronic databases. Search(More)
Nicotine, the addictive component of tobacco products, is an agonist at nicotinic acetylcholine receptors (nAChRs) in the brain. The subtypes of nAChR are defined by their α- and β-subunit composition. The α6β2β3 nAChR subtype is expressed in terminals of dopaminergic neurons that project to the nucleus accumbens and striatum and modulate dopamine release(More)
The Family Smoking Prevention and Tobacco Control Act of 2009 (Public Law 111-31) gave the US Food and Drug Administration (FDA) the responsibility for regulating tobacco products. Nicotine is the primary addictive component of tobacco and its effects can be modulated by additional ingredients in manufactured products. Nicotine acts by mimicking the(More)
In the MCF-7 breast iunior cell line, induction of bulk damage to DNA (measured either as total strand breaks or as double-strand breaks I fails to correspond » ¡Hi the antiprciliferative activity of the demethylepipodo-phyllotoxin derivative, VM-26. In contrast, VM-26 produces an early (within 2-3 h) concentration-dependent reduction in e-myc expression(More)
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