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BACKGROUND Immunotherapy can become a crucial therapeutic option to improve prognosis for lung cancer patients. First clinical trials with therapies targeting the programmed cell death receptor PD-1 and its ligand PD-L1 have shown promising results in several solid tumors. However, in lung cancer the diagnostic, prognostic and predictive value of these(More)
–We estimated the impact of striped bass (Morone saxatilis) pre­ dation on winter-run chinook salmon (Oncorhynchus tshawytscha) with a Bayesian population dynamics model using striped bass and winter-run chinook salmon population abundance data. Winter-run chinook salmon ex­ tinction and recovery probabilities under different future striped bass abundance(More)
The effects of an increased disease mortality rate on the transient and asymptotic dynamics of Chinook salmon (Oncorhynchus tshawytscha) were investigated. Disease-induced mortality of juvenile salmon has become a serious concern in recent years. However, the overall effects of disease mortality on the asymptotic and transient dynamics of adult spawning(More)
BACKGROUND Transcatheter aortic valve implantation (TAVI) has become the treatment of choice in patients with severe aortic valve stenosis who are not eligible for operative replacement and an alternative for those with high surgical risk. Due to high age and smoking history in a high proportion of TAVI patients, suspicious findings are frequently observed(More)
Dedication The authors would like to dedicate this report to the memory of Karen M. Burns. Beginning in the 1990s, Dr. Burns conducted numerous helpful and influential studies of release mortality in Southeast reef fishes. She was missed during the development of this report, but her work continues to inspire release mortality research. vi Executive Summary(More)