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List of Figures Figure 1. Two generalized patterns of evolution of life-history traits. An asterisk denotes an evolutionary change (Waples et al. 10. Time series of Klamath River fall Chinook salmon spawner reduction rate. These rates represent fractions of potential spawners that have been reduced by harvest and harvest-related actions.. 3. Template for(More)
BACKGROUND Immunotherapy can become a crucial therapeutic option to improve prognosis for lung cancer patients. First clinical trials with therapies targeting the programmed cell death receptor PD-1 and its ligand PD-L1 have shown promising results in several solid tumors. However, in lung cancer the diagnostic, prognostic and predictive value of these(More)
–We estimated the impact of striped bass (Morone saxatilis) pre­ dation on winter-run chinook salmon (Oncorhynchus tshawytscha) with a Bayesian population dynamics model using striped bass and winter-run chinook salmon population abundance data. Winter-run chinook salmon ex­ tinction and recovery probabilities under different future striped bass abundance(More)
We have established a new simultaneous positive/nega-tive selection procedure using the Baxter Isolex 300i system. We tested its tumor cell (TC) purging efficacy by tumor contamination tests ex vivo and its safety in a group of 17 breast cancer (BC) patients by measuring hematopoietic recovery after high-dose (HD) therapy and autologous stem cell rescue(More)
The effects of an increased disease mortality rate on the transient and asymptotic dynamics of Chinook salmon (Oncorhynchus tshawytscha) were investigated. Disease-induced mortality of juvenile salmon has become a serious concern in recent years. However, the overall effects of disease mortality on the asymptotic and transient dynamics of adult spawning(More)
Recurrent respiratory papillomatosis (RRP) is a primary benign disease, which is characterized by papilloma-tous growth in the respiratory tract. Malignant transformation occurs in only 3-5% of cases, however, local growth of the benign papillomas is interpreted as clinically malignant in a markedly higher proportion of patients. Local surgical or(More)