Michael S. Lauer

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This document details the procedures and recommendations of the Goals and Metrics Committee of the Strategic Planning Task Force of the American Heart Association, which developed the 2020 Impact Goals for the organization. The committee was charged with defining a new concept, cardiovascular health, and determining the metrics needed to monitor it over(More)
We introduce random survival forests, a random forests method for the analysis of right-censored survival data. New survival splitting rules for growing survival trees are introduced, as is a new missing data algorithm for imputing missing data. A conservation-of-events principle for survival forests is introduced and used to define ensemble mortality, a(More)
BACKGROUND The increase in heart rate that accompanies exercise is due in part to a reduction in vagal tone. Recovery of the heart rate immediately after exercise is a function of vagal reactivation. Because a generalized decrease in vagal activity is known to be a risk factor for death, we hypothesized that a delayed fall in the heart rate after exercise(More)
Philip Greenland, MD, FACC, FAHA, Chair; Joseph S. Alpert, MD, FACC, FAHA; George A. Beller, MD, MACC, FAHA; Emelia J. Benjamin, MD, SCM, FACC, FAHA*†; Matthew J. Budoff, MD, FACC, FAHA‡§ ; Zahi A. Fayad, PhD, FACC, FAHA¶; Elyse Foster, MD, FACC, FAHA#; Mark. A. Hlatky, MD, FACC, FAHA§**; John McB. Hodgson, MD, FACC, FAHA, FSCAI‡§**††; Frederick G. Kushner,(More)
Philip Greenland, MD, FACC, FAHA, Chair; Joseph S. Alpert, MD, FACC, FAHA; George A. Beller, MD, MACC, FAHA; Emelia J. Benjamin, MD, SCM, FACC, FAHA*†; Matthew J. Budoff, MD, FACC, FAHA‡§ ; Zahi A. Fayad, PhD, FACC, FAHA¶; Elyse Foster, MD, FACC, FAHA#; Mark. A. Hlatky, MD, FACC, FAHA§**; John McB. Hodgson, MD, FACC, FAHA, FSCAI‡§**††; Frederick G. Kushner,(More)
OBJECTIVES We sought to determine the association of etiology of constrictive pericarditis (CP), pericardial calcification (CA), and other clinical variables with long-term survival after pericardiectomy. BACKGROUND Constrictive pericarditis is the result of a spectrum of primary cardiac and noncardiac conditions. Few data exist on the cause-specific(More)
The minimal depth of a maximal subtree is a dimensionless order statistic measuring the predictiveness of a variable in a survival tree. We derive the distribution of the minimal depth and use it for high-dimensional variable selection using random survival forests. In big p and small n problems (where p is the dimension and n is the sample size), the(More)
BACKGROUND Abnormal heart rate recovery after symptom-limited exercise predicts death. It is unknown whether this is also true among patients undergoing submaximal testing. OBJECTIVE To test the prognostic implications of heart rate recovery in cardiovascularly healthy adults undergoing submaximal exercise testing. DESIGN Population-based cohort study.(More)
T he International Classification of Diseases, Tenth Revision , defines sudden cardiac death (SCD) as death due to any cardiac disease that occurs out of hospital, in an emergency department, or in an individual reported dead on arrival at a hospital. In addition, death must have occurred within 1 hour after the onset of symptoms. SCD may be due to(More)
BACKGROUND The presence of systemic inflammation determined by elevations in C-reactive protein (CRP) has been associated with persistence of atrial fibrillation (AF). The relationship between CRP and prediction of AF has not been studied in a large population-based cohort. METHODS AND RESULTS CRP measurement and cardiovascular assessment were performed(More)