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Perforin expression can define CD8 positive lymphocyte subsets in pigs allowing phenotypic and functional analysis of natural killer, cytotoxic T, natural killer T and MHC un-restricted cytotoxic…

• Michael S Denyer, Thomas E Wileman, Catrina M A Stirling, Bartek Zuber, H Takamatsu
• Veterinary immunology and immunopathology
• 2006

In this study we have used the expression of perforin to characterize subsets of porcine cytotoxic lymphocytes. Perforin positive lymphocytes expressed both CD2 and CD8alpha, most were small dense… (More)

In vivo depletion of CD8+ T lymphocytes abrogates protective immunity to African swine fever virus.

• C A L Oura, Michael S Denyer, H Takamatsu, Robert Michael Evans Parkhouse
• The Journal of general virology
• 2005

To understand the mechanisms involved in protective immunity to African swine fever virus (ASFV) infection, the observation that infection with the avirulent Portuguese ASFV isolate OUR/T88/3… (More)

Expression of biologically active recombinant porcine GM-CSF by baculovirus gene expression system.

• Shigeki Inumaru, Takehiro Kokuho, +7 authors Haru Takamatsu
• Immunology and cell biology
• 1998

The full length porcine granulocyte/macrophage colony stimulating factor (GM-CSF) cDNA, including secretion signal peptide coding region was recloned into baculovirus transfer vector pAcYM1. The… (More)

Foot-and-mouth disease virus replicates only transiently in well-differentiated porcine nasal epithelial cells.

• Prasannajit Dash, Paul V. Barnett, +6 authors Hiroyuki Takamatsu
• Journal of virology
• 2010

Three-dimensional (3D) porcine nasal mucosal and tracheal mucosal epithelial cell cultures were developed to analyze foot-and-mouth disease virus (FMDV) interactions with mucosal epithelial cells.… (More)

Porcine gammadelta T cells: possible roles on the innate and adaptive immune responses following virus infection.

• Haru-H. Takamatsu, Michael S Denyer, +5 authors Paul V. Barnett
• Veterinary immunology and immunopathology
• 2006

gammadelta T cells recognise different types of antigen in alternative ways to alphabeta T cells, and thus appear to play a complementary role in the immune response. However, unlike alphabeta T… (More)

Cellular immunity in ASFV responses.

• H Takamatsu, Michael S Denyer, +6 authors Fernando Rodríguez
• Virus research
• 2013

African swine fever virus (ASFV) infection usually results in an acute haemorrhagic disease with a mortality rate approaching 100% in domestic pigs. However, pigs can survive infection with… (More)

In vivo depletion of CD 8 + T lymphocytes abrogates protective immunity to African swine fever virus

• C A L Oura, Michael S Denyer, Haru-H. Takamatsu, Robert Michael Evans Parkhouse
• 2005

Received 16 March 2005 Accepted 3 June 2005 To understand the mechanisms involved in protective immunity to African swine fever virus (ASFV) infection, the observation that infection with the… (More)

Analysis of bovine B cell reactive monoclonal antibodies.

• D T Mukwedeya, H Takamatsu, Michael S Denyer, Robert Michael Evans Parkhouse
• Veterinary immunology and immunopathology
• 1996

Monoclonal antibodies (mAbs) submitted to the workshop B cell panel were screened for reactivity with bovine surface immunoglobulin positive (SIg+) cells from tonsil, mesenteric lymph nodes (MLN),… (More)

Equine influenza infections in Great Britain, 1979.

• Roger Burrows, Dr. Alan G. Goodridge, Michael S Denyer, Graham Hutchings, Chrktopher J. Frank
• The Veterinary record
• 1982

Dramatic improvement in FMD DNA vaccine efficacy and cross-serotype antibody induction in pigs following a protein boost.

• Yanmin Li, Catrina M A Stirling, +4 authors Paul V. Barnett
• Vaccine
• 2008

To overcome the low and slow development of humoral antibody often observed with DNA vaccines we applied a prime-boost strategy. When FMD DNA vaccine P1-2A3C3D and pGM-CSF primed pigs were boosted… (More)

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