Michael S. Blum

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The tight junction (TJ) is a specialized intercellular structure responsible for the regulation of ionic and macromolecular flux across cell monolayers. Because plasma leakage is believed to occur mainly across the microvasculature, we hypothesized that microvascular endothelial cells (MVEC) may form more intact, regulatable TJ than other endothelial cell(More)
In the last 5 years, regulatory agencies and drug monitoring centres have been developing computerised data-mining methods to better identify reporting relationships in spontaneous reporting databases that could signal possible adverse drug reactions. At present, there are no guidelines or standards for the use of these methods in routine(More)
BACKGROUND Safe delivery of care depends on effective communication among all health care providers, especially during transfers of care. The traditional medical chart does not adequately support such communication. We designed a patient-tracking tool that enhances provider communication and supports clinical decision making. AIM To develop a(More)
S. HARROCH, M. PALMERI, J. ROSENBLUTH, A. CUSTER, M. OKIGAKI, P. SHRAGER, M. BLUM, J. D. BUXBAUM, AND J. SCHLESSINGER* Department of Pharmacology and the Skirball Institute and Department of Physiology and Neuroscience, New York University Medical Center, New York, New York 10016; Department of Neurobiology and Anatomy, University of Rochester Medical(More)
S. Michael Marcy a, Katrin S. Kohl b,∗, Ron Dagan c, David Nalin d, Michael Blum e, Marcy Connell Jones f, John Hansen g, Jerry Labadie h, Lucia Lee i, Bryan L. Martin j, Katherine O’Brien k, Edward Rothstein l, Patricia Vermeer m, The Brighton Collaboration Fever Working Group n, o, 1 a Harbor-UCLA Medical Center, USA and Kaiser-Permanente Health Care(More)
Fever is a common clinical complaint in adults and children with a variety of infectious illnesses, as well as a frequently reported adverse event following immunization. Although the level of measured temperature indicative of a "fever" was first defined in 1868, it remains unclear what role fever has as a physiologic reaction to invading substances, how(More)
One hundred fifty-eight patients (76 men and 82 women) presenting to an outpatient cardiology clinic with a new complaint of angina were prospectively followed to determine if there was a gender bias in the management of suspected coronary artery disease when physicians trained in cardiology managed their care. Overall, there were no differences in the(More)
The present study evaluated the effect of 25(OH)vitamin D3[25(OH)vit D3] on the phosphaturic action of calcitonin in anesthetized parathyroidectomized rats. In group 1, calcitonin was given intravenously over six clearance periods. In group 2, after three periods of calcitonin given intravenously, 25(OH)vit D3 was added and given together with calcitonin(More)
Renal handling of phosphorus was studied in the following groups of parathyroidectomized rats with maleate-induced Fanconi syndrome: 1) 6 rats receiving intravenous parathyroid hormone, 2) 6 rats receiving intravenous dibutyryl cyclic AMP (DBcAMP), 3) 6 rats undergoing volume expansion with saline, 4) 12 rats receiving intravenous 25 (OH)vitamin D3, 5) 12(More)