Michael Royle

Learn More
PURPOSE In cavernous smooth muscle nitric oxide (NO) activates soluble guanylate cyclase, which catalyzes the synthesis of cyclic guanosine 3',5'-monophosphate, leading to smooth muscle relaxation, increased blood flow and penile erection. The pyrazolopyridine derivative BAY41-2272(More)
We have examined the effect of an inhibitor of Rho-kinase, (+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl) cyclohexanecarboxamide dihydrochloride monohydrate (Y-27632), on the contractions elicited by noradrenergic nerve stimulation and by phenylephrine in the human and rabbit penile corpus cavernosum. In both tissues, after treatment with scopolamine (10(More)
As a Project Manager, your time is far too important to be wasted on mundane tasks like detailed tracking of the dayto-day activities of each of your developers. Wouldn't it be nice if you spent your time negotiating project scope and identifying and removing team impediments? Our experience has shown that consistency in card sizes and estimates allows you(More)
  • 1