Michael Rohn

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Tachykinins, an evolutionary conserved family of peptide hormones in both invertebrates and vertebrates, are produced by neuronal cells as inactive preprotachykinins that are post-translationally processed into different neuropeptides such as substance P, neurokinin A, and neurokinin B. We show here that furin-mediated cleavage of the bovine respiratory(More)
The enteric nervous system contains excitatory and inhibitory neurons, which control contraction and relaxation of smooth muscle cells as well as gastrointestinal motor activity. Little is known about the exact cellular mechanisms of neuronal signal transduction to smooth muscle cells in the gut. Here we generate a c-Kit(CreERT2) knock-in allele to target a(More)
This paper concerns continuous nondisturbing estimation of blood pressure using mechanical plethysmography in connection with standard electrocardiography (ECG). The plethysmography is given by a novel magnetoelastic skin curvature sensor (SC-sensor) applied on the neck over the carotid artery. The sensor consists of a magnetoelastic bilayer partly enclosed(More)
Whole-cell patch-clamp recordings of membrane currents were performed in combination with measurements of mediator secretion from mucosal-type mast cells (rat basophilic leukemia cells, subline 2H3), to determine the involvement of membrane conductances induced upon depletion of intracellular Ca2+ stores. In patch-clamp experiments, ethylene glycol(More)
Gastric motility is controlled at various levels including the enteric nervous system (ENS). The gastric ENS is involved in the regulation of accommodation reflexes as well as of the peristaltic waves which are responsible for grinding and emptying. Polarised projections consisting of ascending cholinergic and descending nitrergic muscle motor neurons make(More)
Introduction Interstitial cell of Cajal (ICC) form a cellular network that is embedded in the musculature of the gastrointestinal tract. Previous studies provided clear evidence that ICC generate a rhythmic pacemaker current which manifests itself as slow-waves in membrane potential of smooth muscle cells resulting in rhythmic bowel contractions. However, a(More)
The development of reliable Automatic Quality Control (AQC) schemes has played a key role in the development of the new high density and high frequency Atmospheric Motion Vector (AMV) products at UW/CIMSS and EUMETSAT. Despite the fact that the AQC schemes in the two organisations differ significantly it has previously been shown that both schemes are(More)
In this work we demonstrate for the first time the micro- and nanostructuring of graphene by means of UV-nanoimprint lithography. Exfoliated graphene on SiO(2) substrates, as well as graphene deposited by chemical vapor deposition (CVD) on polycrystalline nickel and copper, and transferred CVD graphene on dielectric substrates, were used to demonstrate that(More)
quent delivery to the intestine. The smooth muscle cells in this region generate myogenic tone which can be actively inhibited to bring about gastric relaxation1. This occurs during receptive as well as adaptive relaxation2. The relaxation involves parasympathetic innervation via the vagus nerve and, in particular for the adaptive relaxation, the enteric(More)
Enhanced Meteosat wind data sets are provided every 90 minutes together with the Quality Indicator (QI) derived during the quality control of the Meteorological Product Extraction Facility (MPEF) at EUMETSAT. All three channel Cloud Motion Winds (CMW) and clear sky Water Vapour Motion Winds (WVMW) have been passively monitored by comparison to the ECMWF(More)
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