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OBJECTIVE To compare the efficacy of duloxetine with placebo on depression in elderly patients with major depressive disorder. DESIGN Multicenter, 24-week (12-week short-term and 12-week continuation), randomized, placebo-controlled, double-blind trial. SETTING United States, France, Mexico, Puerto Rico. PARTICIPANTS Age 65 years or more with major(More)
Norepinephrine (NE) is a major monoamine neurotransmitter that has widespread effects across multiple brain areas to regulate arousal and stress responses. The underlying function of the NE cortical system is to balance vigilance/scanning behavior with focused attention on novel environmental stimuli and the state of arousal. The central NE system is(More)
There is a critical need for improved departure management during convective weather events in the highly congested airspace in the Northeast and upper Midwest. An early study (Allan, 2001) of the New York Integrated Terminal Weather System (ITWS) prototype suggested that small increases in New York airport departure rates during Severe Weather Avoidance(More)
In order to achieve genuine web intelligence, building some kind of large general machine-readable conceptual scheme (i.e. ontology) seems inescapable. Yet the past 20 years have shown that manual ontology-building is not practicable. The recent explosion of free user-supplied knowledge on the Web has led to great strides in automatic ontology-building, but(More)
BACKGROUND Inhaled hypertonic saline acutely increases mucociliary clearance and, in short-term trials, improves lung function in people with cystic fibrosis. We tested the safety and efficacy of inhaled hypertonic saline in a long-term trial. METHODS In this double-blind, parallel-group trial, 164 patients with stable cystic fibrosis who were at least(More)
INTRODUCTION Neonatal infection is an important cause of morbidity and mortality. Neonatal infection surveillance networks are necessary for defining the epidemiology of infections and monitoring changes over time. DESIGN Prospective multicentre surveillance using a web-based database. SETTING 12 English neonatal units. PARTICIPANTS Newborns admitted(More)
Depression and pain disorders are often diagnosed in the same patients. Here we summarize the shared pathophysiology between both disorders and the importance of addressing all symptoms in patients with comorbid pain and depression. We describe anatomical structures that are activated and/or altered in response to both depression and pain--examples include(More)
A b s t r a c t The National Retail Data Monitor receives data daily from 10,000 stores, including pharmacies, that sell health care products. These stores belong to national chains that process sales data centrally and utilize Universal Product Codes and scanners to collect sales information at the cash register. The high degree of retail sales data(More)
A primary objective of the FAA's ATM functions is to provide fair and equitable access to the National Airspace System. Traditionally, the FAA has interpreted fairness as prioritizing flights on a " first-come, first-served " basis. The allocation procedures introduced under Collaborative Decision Making (CDM), however, represent a departure from this(More)
— Severe weather avoidance programs (SWAP) due to convective weather are common in many of the busiest terminal areas in the US National Airspace System (NAS). In order to make efficient use of available airspace in rapidly evolving convective weather, it is necessary to predict the impacts of the weather on key resources (e.g., departure and arrival routes(More)