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The DCC (deleted in colorectal cancer) gene was identified because it is affected by somatic mutations in colorectal tumors, including allelic losses in greater than 70% of cancers and localized mutations in a subset of cases. The DCC gene also may be inactivated in other tumor types, including cancers of the pancreas, stomach, breast, prostate, and brain,(More)
EXTENDED ABSTRACT In this paper we propose a computationally effective approach to detect multiple structural breaks in the mean occurring at unknown dates. We propose a non-parametric approach that exploits, in the framework of least squares regression trees, the contiguity property of the Fisher grouping method (1958) proposed for grouping a single real(More)
The Deleted in Colorectal Cancer (DCC) gene is a candidate tumor suppressor gene that is predicted to encode a transmembrane polypeptide with strong similarity to the neural cell adhesion molecule (N-CAM) family. Previous studies have suggested that several different N-CAMs, when expressed in non-neuronal cell types can stimulate neurite outgrowth from PC12(More)
a r t i c l e i n f o Facial expression is central to human experience. Its efficiency and valid measurement are challenges that automated facial image analysis seeks to address. Most publically available databases are limited to 2D static images or video of posed facial behavior. Because posed and un-posed (aka " spontaneous ") facial expressions differ(More)
—Facial expression is central to human experience. Its efficient and valid measurement is a challenge that automated facial image analysis seeks to address. Most publically available databases are limited to 2D static images or video of posed facial behavior. Because posed and un-posed (aka " spontaneous ") facial expressions differ along several dimensions(More)