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  • Shu-ichi Okamoto, Mahmoud A. Pouladi, +12 authors Stuart A Lipton
  • Biology, Medicine
  • Nature Medicine
  • 2009 (First Publication: 8 October 2009)
  • Huntington's disease is caused by an expanded CAG repeat in the gene encoding huntingtin (HTT), resulting in loss of striatal and cortical neurons. Given that the gene product is widely expressed, itContinue Reading
  • J. Hodgson, Nadia Agopyan, +16 authors Michael R. Hayden
  • Biology, Medicine
  • Neuron
  • 1999 (First Publication: 1 May 1999)
  • We have produced yeast artificial chromosome (YAC) transgenic mice expressing normal (YAC18) and mutant (YAC46 and YAC72) huntingtin (htt) in a developmental and tissue-specific manner identical toContinue Reading