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Regulation of transcription by a protein methyltransferase.

• Datong Chen, Han Ma, +5 authors Michael R Stallcup
• Science
• 1999

The p160 family of coactivators, SRC-1, GRIP1/TIF2, and p/CIP, mediate transcriptional activation by nuclear hormone receptors. Coactivator-associated arginine methyltransferase 1 (CARM1), a… (More)

Structure and specificity of nuclear receptor-coactivator interactions.

• Beatrice D. Darimont, Richard L. Wagner, +5 authors Keith R. Yamamoto
• Genes & development
• 1998

Combinatorial regulation of transcription implies flexible yet precise assembly of multiprotein regulatory complexes in response to signals. Biochemical and crystallographic analyses revealed that… (More)

Human PAD4 regulates histone arginine methylation levels via demethylimination.

• Yanming Wang, Joanna Wysocka, +12 authors Scott A Coonrod
• Science
• 2004

Methylation of arginine (Arg) and lysine residues in histones has been correlated with epigenetic forms of gene regulation. Although histone methyltransferases are known, enzymes that demethylate… (More)

GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors.

• Heng Hong, K. Pollard JP Duminy David Wiese Virat Kohli, Michael J Garabedian, Michael R Stallcup
• Molecular and cellular biology
• 1997

After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation. A search for possible coactivators for… (More)

The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules

• Robert E. Collins, Jeffrey P. Northrop, +4 authors Xiaodong Cheng
• Nature Structural &Molecular Biology
• 2008

Histone modifications have important roles in transcriptional control, mitosis and heterochromatin formation. G9a and G9a-like protein (GLP) are euchromatin-associated methyltransferases that repress… (More)

GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors.

• Heng Hong, K. Pollard JP Duminy David Wiese Virat Kohli, Alpa Trivedi, Deborah L. Johnson, Michael R Stallcup
• Proceedings of the National Academy of Sciences…
• 1996

The yeast two-hybrid system was used to isolate a clone from a 17-day-old mouse embryo cDNA library that codes for a novel 812-aa long protein fragment, glucocorticoid receptor-interacting protein 1… (More)

Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): multiple motifs with different binding specificities.

• Xianting Ding, Carol M. Anderson, +4 authors Michael R Stallcup
• Molecular endocrinology
• 1998

The activity of the AF-2 transcriptional activation function of nuclear receptors (NR) is mediated by the partially homologous transcriptional coactivators, glucocorticoid receptor interacting… (More)

Estrogen receptor activation function 1 works by binding p160 coactivator proteins.

• Paul D. Webb, Phuong Thê Nguyên, +10 authors Peter J. Kushner
• Molecular endocrinology
• 1998

Estrogen receptor-alpha contains two transactivation functions, a weak constitutive activation function (AF-1) and a hormone-dependent activation function (AF-2). AF-2 works by recruiting a large… (More)

Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1

• Brian D. Strahl, Scott D Briggs, +8 authors C David Allis
• Current Biology
• 2001

Posttranslational modifications of histone amino termini play an important role in modulating chromatin structure and function. Lysine methylation of histones has been well documented, and recently… (More)

Methylation of histone H3 by coactivator-associated arginine methyltransferase 1.

• B T Schurter, Stephen S Koh, +7 authors Dana W Aswad
• Biochemistry
• 2001

The preferential in vitro methylation of histone H3 by coactivator-associated arginine methyltransferase 1 (CARM1) has been proposed as a basis for its ability to enhance gene transcription [Chen,… (More)

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