Michael R. Saunders

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For efficient prevention of viral infections and cross protection, simultaneous targeting of multiple viral epitopes is a powerful strategy. Llama heavy chain antibody fragments (VHH) against the trimeric envelope proteins of Respiratory Syncytial Virus (Fusion protein), Rabies virus (Glycoprotein) and H5N1 Influenza (Hemagglutinin 5) were selected from(More)
Intensive plantation management of high-value hardwoods, such as black walnut (Juglans nigra L.), is focused on maximizing both stem form and growth at the stand and tree level. While significant research has focused on genetic improvement in black walnut, little is known about the production ecology of this species in plantation settings. The aim of this(More)
Forest plantations in the northeastern United States comprise a small proportion of the total forest area. Most plantations are typically softwood dominated and managed for sawlog and pulpwood production, while high-yield hardwood plantations for bioenergy feedstocks have not been as widely investigated. The objective of this study was to compare the(More)
Bispecific antibodies are of great interest due to their ability to simultaneously bind and engage different antigens or epitopes. Nevertheless, it remains a challenge to assemble, produce and/or purify them. Here we present an innovative dual anti-idiotypic purification process, which provides pure bispecific antibodies with native immunoglobulin format.(More)
Leaf area index (LAI) affects forest-atmosphere fluxes and light interception rates and thus influences forest productivity. Early silvicultural treatments affect LAI partitioning among species of different shade tolerance in natural stands due to changes in composition and structure. We examined effects of species compositional objectives (conifer,(More)
When a tree dies, it continues to play an important ecological role within forests. Coarse woody debris (CWD), including standing deadwood (SDW) and downed deadwood (DDW), is an important functional component of forest ecosystems, particularly for many dispersal-limited saproxylic taxa and for metapopulation dynamics across landscapes. Processes, such as(More)
FcRn is a key player in several immunological and non-immunological processes, as it mediates maternal-fetal transfer of IgG, regulates the serum persistence of IgG and albumin, and transports both ligands between different cellular compartments. In addition, FcRn enhances antigen presentation. Thus, there is an intense interest in studies of how FcRn binds(More)
VHH are polypeptides (15 kDa) derived from the variable domain of single heavy-chain antibodies of Camelidae. They represent the smallest antigen-binding fragment of an antibody (human IgG = 150 kDA). VHH are currently being explored for a number of applications. Anti-rabies virus VHH were cloned from lymphocytes of vaccinated llamas and selected for their(More)
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