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Harnessing the power of RADseq for ecological and evolutionary genomics
TLDR
This Review provides a comprehensive discussion of RADseq methods to aid researchers in choosing among the many different approaches and avoiding erroneous scientific conclusions from RADseq data, a problem that has plagued other genetic marker types in the past.
Rapid and cost-effective polymorphism identification and genotyping using restriction site associated DNA (RAD) markers.
TLDR
The results demonstrate that RAD markers, and the method to develop a RAD marker microarray resource, allow high-throughput, high-resolution genotyping in both model and nonmodel systems.
Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma
TLDR
This work uses mosaic analysis with double markers in mice to model gliomagenesis by initiating concurrent p53/Nf1 mutations sporadically in neural stem cells (NSCs), and suggests OPCs as the cell of origin in this model, even when initial mutations occur in NSCs.
Genotyping‐by‐sequencing in ecological and conservation genomics
TLDR
This special issue on ‘Genotyping-by-Sequencing in Ecological and Conservation Genomics’ represents a diverse set of empirical and theoretical studies that demonstrate both the utility and some of the challenges of GBS in ecological and conservation genomics.
Genomic patterns of introgression in rainbow and westslope cutthroat trout illuminated by overlapping paired‐end RAD sequencing
TLDR
A novel approach, overlapping paired‐end RAD sequencing, is presented, to generate RAD contigs of >300–400 bp that provide sufficient flanking sequence for design of high‐throughput SNP genotyping arrays and strict filtering to identify duplicate paralogous loci.
Genetic Architecture of Migration-Related Traits in Rainbow and Steelhead Trout, Oncorhynchus mykiss
TLDR
An experimental cross derived from wild resident rainbow and wild migratory steelhead trout from Southeast Alaska and high throughput restriction-site associated DNA (RAD) tag sequencing is performed to identify the number, position, and relative contribution of genetic effects on a suite of 27 physiological and morphological traits associated with the migratory life history in this species.
Evaluating Adaptive Divergence Between Migratory and Nonmigratory Ecotypes of a Salmonid Fish, Oncorhynchus mykiss
TLDR
This study uses population genomics in a nonmodel fish species, rainbow trout (Oncorhynchus mykiss), to better understand adaptive divergence between migratory and nonmigratory ecotypes and to further understand about the genetic basis of migration.
Rapid parallel evolution of standing variation in a single, complex, genomic region is associated with life history in steelhead/rainbow trout
TLDR
Genotype data from 95 single nucleotide polymorphisms are used and show that the distribution of variation in a large region of one chromosome, Omy5, is strongly associated with life-history differentiation in multiple above-barrier populations of rainbow trout and their anadromous steelhead ancestors.
Thermal adaptation and acclimation of ectotherms from differing aquatic climates
TLDR
It is demonstrated that aquatic species can evolve adaptive responses to thermal stress and provide insight for understanding how climate change may impact ectotherms.
The evolutionary basis of premature migration in Pacific salmon highlights the utility of genomics for informing conservation
TLDR
The results reveal that complex adaptive variation can depend on rare mutational events at a single locus, and demonstrate that CUs reflecting overall genetic differentiation can fail to protect evolutionarily significant variation that has substantial ecological and societal benefits, and suggest that a supplemental framework for protecting specific adaptive variation will sometimes be necessary.
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