Michael R. Leuze

Learn More
The Carbohydrate-Active Enzyme (CAZy) database provides a rich set of manually annotated enzymes that degrade, modify, or create glycosidic bonds. Despite rich and invaluable information stored in the database, software tools utilizing this information for annotation of newly sequenced genomes by CAZy families are limited. We have employed two annotation(More)
Since the first two complete bacterial genome sequences were published in 1995, the science of bacteria has dramatically changed. Using third-generation DNA sequencing, it is possible to completely sequence a bacterial genome in a few hours and identify some types of methylation sites along the genome as well. Sequencing of bacterial genome sequences is now(More)
Summary form only given. We highlight a fruitful interplay between biology and computation. The sequencing of complete genomes from multiple organisms has revealed that most differences in organism complexity are due to elements of gene regulation that reside in the non protein coding portions of genes. Both within and between species, transcription factor(More)
Despite its potential importance in obesity and related disorders, little is known about regulation of lipogenesis in human adipose tissue. To investigate this area at the molecular and mechanistic levels, we studied lipogenesis and the regulation of 1 of its core enzymes, fatty acid synthase (FAS), in human adipose tissue in response to hormonal and(More)
Commonly used matrix ordering techniques are designed to minimize fill, i.e., they are designed to minimize the number of zero elements which become nonzero during matrix factorization by Gaussian elimination. If Gaussian elimination is to be implemented on a parallel machine, however, minimum fill orderings are not necessarily optimal. Rather, the primary(More)
MicroRNAs are important regulators of gene expression, acting primarily by binding to sequence-specific locations on already transcribed messenger RNAs (mRNA) and typically down-regulating their stability or translation. Recent studies indicate that microRNAs may also play a role in up-regulating mRNA transcription levels, although a definitive mechanism(More)
The development of computing systems with large numbers of processors has been motivated primarily by the need to solve large, complex problems more quickly than is possible with uniprocessor systems. Traditionally, multiprocessor systems have been uniprogrammed, i.e., dedicated to the execution of a single set of related processes, since this approach(More)