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Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair
Summary SLX4 binds to three nucleases (XPF-ERCC1, MUS81-EME1, and SLX1), and its deficiency leads to genomic instability, sensitivity to DNA crosslinking agents, and Fanconi anemia. However, it is… Expand
TRAIP is a master regulator of DNA interstrand cross-link repair
Cells often use multiple pathways to repair the same DNA lesion, and the choice of pathway has substantial implications for the fidelity of genome maintenance. DNA interstrand crosslinks covalently… Expand
Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms
- Michael R G Hodskinson, Alice Bolner, +11 authors Puck Knipscheer
- Chemistry, Medicine
- 1 March 2020
Acetaldehyde is a highly reactive, DNA-damaging metabolite that is produced upon alcohol consumption 1 . Impaired detoxification of acetaldehyde is common in the Asian population, and is associated… Expand
Group-2 innate lymphoid cell-dependent regulation of tissue neutrophil migration by alternatively activated macrophage-secreted Ear11
Type-2 immunity is characterised by interleukin (IL)-4, IL-5 and IL-13, eosinophilia, mucus production, IgE, and alternatively activated macrophages (AAM). However, despite the lack of neutrophil… Expand
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans
Summary Reactive aldehydes arise as by-products of metabolism and are normally cleared by multiple families of enzymes. We find that mice lacking two aldehyde detoxifying enzymes, mitochondrial ALDH2… Expand
"Ring-fencing" BRCA1 tumor suppressor activity.
BRCA1 is a crucial human breast and ovarian cancer tumor suppressor gene. The article by Drost et al. in this issue of Cancer Cell together with a recent paper in Science now provide a clearer… Expand