Michael R Burke

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Most of the currently used methods for functional brain imaging do not visualize neuronal activity directly but rather rely on the elicited hemodynamic and/or metabolic responses. Glutamate, the major excitatory neurotransmitter, plays an important role in the neurovascular/neurometabolic coupling, but the specific mechanisms are still poorly understood. To(More)
Deep unification(constraint-)based grammars are usually hand-crafted. Scaling such grammars from fragments to unrestricted text is time-consuming and expensive. This problem can be exacerbated in multilingual broad-coverage grammar development scenarios. Cahill et al. (2002, 2004) and O’Donovan et al. (2004) present an automatic f-structure annotation-based(More)
OBJECTIVE Genetic differences between subtypes of HIV-1, even when not associated with key resistance mutations, are known to affect baseline susceptibility to specific antiretroviral drugs and resistance-development pathways. We studied the prevalence and patterns of non-nucleoside reverse transcriptase inhibitor (NNRTI)-associated mutations in HIV-1(More)
Plasmacytoid dendritic cells (PDC) constitute a distinct subset of DC found in human peripheral lymph nodes (LN), but little is known about their function. Cell suspensions were prepared from tumor draining LN (n=20) and control LN (n=11) of women undergoing surgical resection for primary breast cancer and elective surgery for benign conditions,(More)
Susceptibility weighted imaging depicts the perivenous extent of multiple sclerosis white matter lesions (MS-WML) in vivo by directly visualizing their centrally running vein. The aim of this study was to investigate the specificity of this finding for MS. Fifteen patients with MS and 15 patients with microangiopathic white matter lesions (mWML) underwent(More)
PURPOSE Therapy with TNFa blocking agents has been associated with increased rate of anti-nuclear antibodies (ANA) and rare cases of lupus like syndromes. Our aim was to prospectively analyze a wide array of autoantibodies in rheumatoid arthritis (RA) patients before and 14 weeks after starting infliximab. MATERIAL AND METHODS In this study, 26(More)
OBJECTIVES To assess the effect of vaccination against streptococcus pneumoniae on the generation of autoantibodies in patients with SLE. MATERIALS AND METHODS Twenty-four consecutive patients with SLE were vaccinated against streptococcus pneumoniae. Assessment was performed the day of vaccination and 2 months later and included evaluation of disease(More)
PROBLEM Systemic lupus erythematosous (SLE) is a chronic disease with a broad spectrum of clinical and immunological manifestations, therefore, this condition may be frequently misdiagnosed. The current study was conducted to determine the prevalence of undiagnosed SLE among a cohort of infertile women. METHOD OF STUDY Screening was performed using(More)
New languages for distributed memorycompilation, including High Performance Fortran (HPF), provide user directives for partitioning data among processors to specify parallelism. We believe that it will be important for distributed memory compilers for these languages to provide not only eeciency close to a handwritten message passing program, but also(More)
River systems have been altered worldwide by dams and diversions, resulting in a broad array of environmental impacts. The use of a process-based, hierarchical framework for assessing environmental impacts of dams is explored here in terms of a case study of the Kootenai River, western North America. The goal of the case study is to isolate and quantify the(More)