Michael Quigley

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For a long time, the second-hand retail market was the preserve of the charity shop. However, the advent of services like eBay has massively increased its prominence. In this paper we describe a novel Internet of Things-based approach to enhancing the second-hand retail experience by augmenting items with their provenance. After a discussion of the(More)
STUDY OBJECTIVES To explore the sleep onset process in primary insomnia patients, new rules for scoring 4-second epochs were implemented to score sleep and artifacts during initial sleep onset. Conventional scorings in 20-second and 60-second epochs were also obtained. METHODS The start of the initial 60-second epoch of stage 1 was used to define "time(More)
Introductory Paragraph CD8 + T cells in chronic viral infections like HIV develop functional defects such as loss of IL-2 secretion and decreased proliferative potential that are collectively termed exhaustion 1. Exhausted T cells express increased levels of multiple inhibitory receptors, such as Programmed Death 1 (PD-1) 2,3 that contribute to impaired(More)
The monoclonal antibodies ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1) have shown remarkable antitumor activity in an increasing number of cancers. When combined, ipilimumab and nivolumab have demonstrated superior activity in patients with metastatic melanoma (CHECKMATE-067). Here we describe the preclinical development strategy that predicted these(More)
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