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Carcinoma-associated fibroblasts (CAFs) that express α-smooth muscle actin (αSMA) contribute to cancer progression, but their precise origin and role are unclear. Using mouse models of inflammation-induced gastric cancer, we show that at least 20% of CAFs originate from bone marrow (BM) and derive from mesenchymal stem cells (MSCs). αSMA+ myofibroblasts(More)
The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. experiments and histology, the in vitro experiments, flow cytometry, and qRT-PCRs and contributed collection and analysis of the data. Y.K. performed the animal experiments (except for nos. 3 and 9 to 14 in table S1) and qRT-PCR arrays and(More)
OBJECTIVE Stromal cell-derived factor-1 (SDF-1/CXCL12), the main ligand for CXCR4, is overexpressed in human cancer. This study addressed the precise contribution of SDF-1 to gastric carcinogenesis. DESIGN SDF-1 transgenic mice were created and a Helicobacter-induced gastric cancer model was used in combination with H/K-ATPase-IL-1β mice. Gastric tissue(More)
The gastrointestinal epithelium is characterized by a high turnover of cells and intestinal stem cells predominantly reside at the bottom of crypts and their progeny serve to maintain normal intestinal homeostasis. Accumulating evidence demonstrates the pivotal role of a niche surrounding intestinal stem cells in crypts, which consists of cellular and(More)
The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. experiments and histology, the in vitro experiments, flow cytometry, and qRT-PCRs and contributed collection and analysis of the data. Y.K. performed the animal experiments (except for nos. 3 and 9 to 14 in table S1) and qRT-PCR arrays and(More)
Esophageal adenocarcinoma (EAC), with its precursor lesion Barrett's esophagus (BE), accounts for 2% of all cancer-related deaths and has a very poor prognosis with a median survival of less than one year. In addition, the prevalence of BE is rapidly rising in the Western World, resulting in a large number of individuals " at risk " for this disease.(More)
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