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Chemokine receptors, particularly CCR5 and CXCR4, act as essential coreceptors in concert with CD4 for cellular entry by human immunodeficiency virus type 1 (HIV-1; reviewed in [1]). But infection of CD4(-) cells has also been encountered in various tissues in vivo, including astrocytes, neurons and microvascular endothelial cells of the brain [2] [3] [4](More)
Prior experiments in explants of human lymphoid tissue have demonstrated that human immunodeficiency virus type 1 (HIV-1) productively infects diverse cellular targets including T cells and tissue macrophages. We sought to determine the specific contribution of macrophages and T cells to the overall viral burden within lymphoid tissue. To block infection of(More)
Paleographers study ancient and historical handwriting in order to learn more about documents of significant interest and their creators. Computational tools and methods can aid this task in numerous ways, particularly for languages and scripts that are not widely known today. One project currently underway seeks to gather a collection of securely dated(More)
We introduce what we call the principal subalgebra of a lattice vertex (super) algebra associated to an arbitrary Z-basis of the lattice. In the first part (to appear), the second author considered the case of positive bases and found a description of the principal subalgebra in terms of generators and relations. Here, in the most general case, we obtain a(More)
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