Michael Peller

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Blood oxygenation level-dependent (BOLD) contrast MRI is a potential method for a physiological characterization of tissue beyond mere morphological representation. The purpose of this study was to develop evaluation techniques for such examinations using a hyperoxia challenge. Administration of pure oxygen was applied to test these techniques, as pure(More)
Thermosensitive liposomes are a promising tool for external targeting of drugs to solid tumors when used in combination with local hyperthermia or high intensity focused ultrasound. In vivo results have demonstrated strong evidence that external targeting is superior over passive targeting achieved by highly stable long-circulating drug formulations like(More)
The purpose of this study was to characterize T(1), particularly in the hyperthermia temperature range (ca. 37-44 degrees C), in order to control regional hyperthermia with MR monitoring using 0.2 Tesla, and to improve T(1) mapping. A single-slice and a new multislice "T One by Multiple Read-Out Pulses" (TOMROP) pulse sequence were used for fast T(1)(More)
The purpose of this study was to evaluate an optimized multislice acquisition technique for oxygen-enhanced MRI of the lung using slice-selective inversion and refocusing pulses in combination with parallel imaging. An inversion recovery HASTE sequence was implemented with respiratory triggering to perform imaging in end-expiration and with ECG triggering(More)
Flip-angle-optimized fast dynamic T1 mapping ELECTRONIC PREPRINT VERSION: Not for commercial sale or for any systematic external distribution by a third party Final version: Magn Reson Med (in press). Abstract Purpose: To analyze the flip-angle dependence and to optimize the statistical precision of a fast three-dimensional T 1-mapping technique based on(More)
PURPOSE To analyze the flip angle dependence and to optimize the statistical precision of a fast three-dimensional (3D) T1 mapping technique based on the variable flip angle (VFA) method. The proposed single flip angle (1FA) approach acquires only a single 3D spoiled gradient echo data set for each time point of the dynamical series in combination with a(More)
Introduction: Parallel imaging is routinely used for clinical and research MRI of humans. For investigation of small animals , however, parallel acquisition techniques are not well established since many high-field MRI systems still lack the required multi-channel capabilities as well as appropriate multi-element RF coils, and because of substantial(More)
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