Michael Peller

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The aim of this study was to propose and evaluate a methodology to analyze simultaneously acquired T2*-weighted dynamic susceptibility contrast (DSC) MRI and T(1)-weighted dynamic contrast enhanced (DCE) MRI data. Two generalized models of T2*-relaxation are proposed to account for tracer leakage, and a two-compartment exchange model is used to separate(More)
PURPOSE To implement and evaluate the accuracy of non-invasive temperature mapping using MRI methods based on the chemical shift (CS) and T1 relaxation in media of various heterogeneity during focal (laser) and external thermal energy deposition. MATERIALS AND METHODS All measurements were performed on a 1.5 T superconducting clinical scanner using the(More)
The behavior of the signal intensity in MRI of human lungs was investigated during inhalation of pure oxygen. Nine volunteers were examined, five using a breath-hold and four using a non-breath-hold technique. Four coronal slices were acquired in each volunteer using an inversion recovery turbo spin-echo sequence. The inversion time of the sequence was(More)
The purpose of this study was to characterize T(1), particularly in the hyperthermia temperature range (ca. 37-44 degrees C), in order to control regional hyperthermia with MR monitoring using 0.2 Tesla, and to improve T(1) mapping. A single-slice and a new multislice "T One by Multiple Read-Out Pulses" (TOMROP) pulse sequence were used for fast T(1)(More)
The purpose of this study was to evaluate an optimized multislice acquisition technique for oxygen-enhanced MRI of the lung using slice-selective inversion and refocusing pulses in combination with parallel imaging. An inversion recovery HASTE sequence was implemented with respiratory triggering to perform imaging in end-expiration and with ECG triggering(More)
Thermosensitive liposomes are a promising tool for external targeting of drugs to solid tumors when used in combination with local hyperthermia or high intensity focused ultrasound. In vivo results have demonstrated strong evidence that external targeting is superior over passive targeting achieved by highly stable long-circulating drug formulations like(More)
Fragestellung: Die regionale Tiefenhyperthermie in Kombination mit Chemotherapie und/oder Radiotherapie ist ein vielversprechendes Behandlungskonzept für lokal fortgeschrittene, tiefliegende Tumoren. Ziel dieses Projektes ist die nichtinvasive, dreidimensionale Darstellung der Gewebsveränderungen und der Temperaturverteilungen während der regionalen(More)
An inversion recovery true fast imaging with steady precession (FISP) pulse sequence was developed to carry out fast imaging of the lungs at 0.2 T. Using this sequence, oxygen-enhanced magnetic resonance (MR) lung imaging was performed on healthy volunteers. The lungs showed signal enhancement (11.7% +/- 3.8%) when breathing 100% oxygen. Using inversion(More)
Regional hyperthermia in combination with chemotherapy and/or radiotherapy has proven to be an effective treatment concept for locally advanced deep-seated tumors. Simultaneous MR-imaging could be a promising approach for therapy optimization. Purpose of this study was the in vivo investigation of temperature induced longitudinal relaxation time (T(1)) and(More)
BACKGROUND Local hyperthermia has been shown to be an effective adjuvant therapy for cancer. However, progress in this treatment modality requires the non-invasive assessment of temperature distribution in the entire tumour to enable administration of an efficient thermal dose to all tumour areas. Magnetic resonance (MR) imaging offers a promising tool to(More)