Learn More
In recent years, various intervention strategies have reduced malaria morbidity and mortality, but further improvements probably depend upon development of a broadly protective vaccine. To better understand immune requirement for protection, we examined liver-stage immunity after vaccination with irradiated sporozoites, an effective though logistically(More)
Motivated by the discretization problem in isogeometric analysis, we consider the challenge of segmenting a contractible boundary-represented solid into a small number of topological hexahedra. A satisfactory segmentation of a solid must eliminate non-convex edges because they prevent regular parameterizations. Our method works by searching a sufficiently(More)
• Segmentation of a 3D solid without non-convex edges into topological hexahedra. • Method is based on the edge graph of the solid. • Decomposition is done by means of simple combinatorial and geometric criteria. • Number of resulting topological hexahedra is small. a b s t r a c t We present a novel technique for segmenting a three-dimensional solid with a(More)
Geodesics are a generalisation of straight lines to Riemannian manifolds and other spaces equipped with an affine connection. Interpolation and approximation problems motivate analogous generalisations of cubic polynomials. There are several approaches. Cubic polynomials in Euclidean space are critical points of the mean norm-squared acceleration,(More)
The finite flag-transitive linear spaces which have an insoluble automorphism group were given a precise description in [BDD + 90], and their classification has recently been completed (see [Lie98] and [Sax02]). However, the remaining case where the automorphism group is a subgroup of one-dimensional affine transformations has not been classified and bears(More)
A class of discrete-time random processes that have seen a wide variety of applications consists of a linear state-space model whose parameters are modulated by the state of a finite-state Markov chain. A typical way to filter such processes is with collapsing methods, which approximate the underlying distribution by a mixture of Gaussians indexed by the(More)
  • 1