Michael Patrick Kelso

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Phosphodiesterase-5 (PDE5) inhibitors (sildenafil, tadalafil, and vardenafil) are agents currently in clinical use for nonmalignant conditions. We report the use of PDE5 inhibitors as modulators of the antitumor immune response. In several mouse tumor models, PDE5 inhibition reverses tumor-induced immunosuppressive mechanisms and enables a measurable(More)
The effects of quasi-steady loading on a virtual spur gear model." MS ii To my beautiful wife Jennifer whose support has been unwavering and to my son Jack for making life far more interesting and enjoyable iii ACKNOWLEDGMENTS The author would like to thank a number of people for their assistance with this thesis. First, thanks must be given to Professors(More)
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