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Normal reference values for flow cytometric immunophenotypic lymphocyte markers for cord blood (CB) were determined using sufficient numbers of subjects for clinical laboratory use. Samples from 202 normal gestations were processed by whole blood lysis and analyzed in the following combinations: CD14/45, CD4/3, CD8/3, CD45RA/4, CD29/4, CD56/3, Cd19/3,(More)
IMPORTANCE NEC is a common and severe complication in premature neonates, particularly those with very-low-birth-weight (VLBW, <1500 g at birth). Probiotics including lactobacillus rhamnosus GG (LGG) proved effective in preventing NEC in preterm infants in several RCTs. OBJECTIVE Lactoferrin, a mammalian milk glycoprotein involved in innate immune host(More)
BACKGROUND The clinically appropriate range for oxygen saturation in preterm infants is unknown. Previous studies have shown that infants had reduced rates of retinopathy of prematurity when lower targets of oxygen saturation were used. METHODS In three international randomized, controlled trials, we evaluated the effects of targeting an oxygen saturation(More)
OBJECTIVE To assess the efficacy of recombinant human erythropoietin (rHuEpo) in the treatment of the anemia of prematurity. METHODOLOGY A double-blind, placebo-controlled study was conducted on 80 preterm infants (< or = 32 weeks; postnatal age, 2 to 8 weeks; central hematocrit < or = 35%). Patients were randomly assigned to receive subcutaneous rHuEpo(More)
OBJECTIVES To comprehensively identify preterm infants likely to require blood transfusion and to investigate the effectiveness of recombinant erythropoietin in this high risk subgroup. DESIGN Double blind randomised controlled trial. SETTING Neonatal Intensive Care Unit, Middlemore Hospital, Auckland, New Zealand. PATIENTS Preterm infants < 33 weeks(More)
In order to determine the utility of amniocentesis for detecting subclinical chorioamnionitis in asymptomatic afebrile women in preterm labor with intact membranes, we enrolled 47 women between 27-32 weeks' gestation in a prospective study. After enrollment, 38 women fulfilled all clinical and laboratory criteria for the study; nine women were excluded(More)
Sickle cell disease (SCD) is characterized by increased cellular adhesiveness, hemolytic anemia, hemostatic activation , vaso-occlusion and thrombosis. We found that patients with SCD in steady state have elevated plasma levels of the platelet protein thrombospondin-1 (TSP1) and that these levels are associated with vaso-occlusive complications and a(More)
OBJECTIVE To determine if timing of cord clamping affects blood flow in the upper body, as measured by flow in the superior vena cava (SVC). DESIGN Observational study. SETTING Neonatal Unit, Middlemore Hospital, Auckland, New Zealand. PATIENTS 30 preterm infants <30 weeks' gestational age. INTERVENTION Cord clamping was immediate in 17 infants and(More)
Platelets are activated in sickle cell disease (SCD), and particularly during vaso-occlusive episodes (VOE). Thrombospondin-1 (TSP1), a major secretory product of activated platelets, is increased in the circulation in VOE and binds to sickle red blood cells (RBC) promoting vascular adhesion. Thus, we hypothesized that TSP1 may represent a plasma biomarker(More)