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Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis
TLDR
It is proposed that molecular interactions between initiation and termination domains are limited to competing PCP docking sites, and the fact that (R)-pantetheine can support CAR activity for mixtures of the isolated domains suggests directions for further development of CAR as a biocatalyst.
Subunit Arrangement in GpsB, a Regulator of Cell Wall Biosynthesis
TLDR
An analysis of the arrangement of subunits in Listeria monocytogenes GpsB by small-angle X-ray scattering shows an elongated shape with residues critical for interaction with PBP1 and the cell membrane clustered at one end of the molecule, consistent with a role for GPSB in modulating the synthesis of the cell wall.
The herpes viral transcription factor ICP4 forms a novel DNA recognition complex
TLDR
The crystal structure of the functionally essential ICP4 DNA binding domain in complex with a segment from its own promoter, revealing a novel homo-dimeric fold is presented, indicating that, in addition to the globular domain, a flanking intrinsically disordered region also recognizes DNA.
The role of fibrillin and microfibril binding proteins in elastin and elastic fibre assembly
TLDR
Fibrillin microfibrils mediate cell signalling via integrin and syndecan receptors, and microfibils sequester transforming growth factor (TGF)β family growth factors within the matrix to provide a tissue store which is critical for homeostasis and remodelling.
Lysyl oxidase–like 2 (LOXL2)–mediated cross-linking of tropoelastin
TLDR
The data suggest that LOXL2 could participate in elastogenesis in vivo and could be used as a means of cross‐linking TE in vitro for biomimetic and cell‐compatible tissue engineering purposes.
Structural characterization of twisted gastrulation provides insights into opposing functions on the BMP signalling pathway
TLDR
Together these data suggest that Tsg functions as a BMP-agonist by inducing conformational change in chordin making it more susceptible to tolloid cleavage and as aBMP-antagonist either independently or via a chordin-mediated mechanism.
The C-terminal dimerization domain of the respiratory mucin MUC5B functions in mucin stability and intracellular packaging before secretion
TLDR
An asymmetric, elongated twisted structure is identified in the C-terminal dimerization domain of MUC5B in compaction of mucin chains during granular packaging via interactions with the N-Terminal multimerization domain, suggesting a role for this domain in mucociliary clearance.
Mammalian tolloid proteinases: role in growth factor signalling
TLDR
All members of the tolloid family bind the N terminus of latent TGF β‐binding protein‐1, providing support for their role in TGFβ signalling.
Transglutaminase-Mediated Cross-Linking of Tropoelastin to Fibrillin Stabilises the Elastin Precursor Prior to Elastic Fibre Assembly
TLDR
Insight is provided into the interactions of tropoelastin and fibrillin and how cross-link formation stabilises the elastin precursor so it is primed for elastic fibre assembly and a long-range stabilising effect of cross-linking is suggested.
Internal cleavage and synergy with twisted gastrulation enhance BMP inhibition by BMPER
TLDR
It is shown that human BMPER binds to Tsg through the N-terminal BMP-binding region which alone more potently inhibits B MP-4 signalling than full-length B MPER, suggesting a synergistic function to dampen BMP activity.
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