Michael P. Hedrick

Learn More
While the endogenous fatty acid amide oleamide has hypnotic properties, neither the breadth of its behavioral actions nor the mechanism(s) by which these behaviors may be mediated has been elucidated. Therefore, the effects of oleamide on the performance of rats in tests of motor function, analgesia, and anxiety were investigated. Oleamide reduced the(More)
Herein we present the outcome of a high throughput screening (HTS) campaign-based strategy for the rapid identification and optimization of selective and general chemotypes for both kappa (κ) opioid receptor (KOR) activation and inhibition. In this program, we have developed potent antagonists (IC(50) < 120 nM) or agonists of high binding affinity (K(i) < 3(More)
Today's large, public databases of protein-small molecule interaction data are creating important new opportunities for data mining and integration. At the same time, new graphical user interface-based workflow tools offer facile alternatives to custom scripting for informatics and data analysis. Here, we illustrate how the large protein-ligand database(More)
The meeting was called to order at 2:05 p.m. 1. Approval of the agenda M/S/P (Murray/Stryker) to approve. 2. Approval of the 2/2/16 minutes M/S/P (Watnik/Murray) to approve, amended M/S/P (Karplus/Watnik) to change " require " to " make explicit the requirements of particular assignments and " in the third sentence of the second paragraph of Item 3.A and(More)
GE Subcommittee Chair Glass presented a PowerPoint describing the process and principles used in drafting the document. The Academic Senate approved the GE framework with 14-15 CIC 38, recommendation for the cluster program with 14-15 CIC 40, and graduation requirement overlays as part of 15-16 CIC 5. The process for outcomes included weekly meetings of the(More)
Pharmacological treatment for methamphetamine addiction will provide important societal benefits. Neurotensin receptor NTR1 and dopamine receptor distributions coincide in brain areas regulating methamphetamine-associated reward, and neurotensin peptides produce behaviors opposing psychostimulants. Therefore, undesirable methamphetamine-associated(More)
Cellular proteins that fail to fold properly result in inactive or disfunctional proteins that can have toxic functions. The unfolded protein response (UPR) is a two-tiered cellular mechanism initiated by eukaryotic cells that have accumulated misfolded proteins within the endoplasmic reticulum (ER). An adaptive pathway facilitates the clearance of the(More)
Binding of leukocyte specific integrin CD11b/CD18 to its physiologic ligands is important for the development of normal immune response in vivo. Integrin CD11b/CD18 is also a key cellular effector of various inflammatory and autoimmune diseases. However, small molecules selectively inhibiting the function of integrin CD11b/CD18 are currently lacking. We(More)
  • 1