Gordon Y. C. Cheung12
Min Li9
Frank R. DeLeo7
Binh An Diep7
12Gordon Y. C. Cheung
9Min Li
7Frank R. DeLeo
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  • Shu Y. Queck, Burhan A. Khan, Rong Wang, Thanh-Huy L. Bach, Dorothee Kretschmer, Liang Chen +4 others
  • 2009
Bacterial virulence and antibiotic resistance have a significant influence on disease severity and treatment options during bacterial infections. Frequently, the underlying genetic determinants are encoded on mobile genetic elements (MGEs). In the leading human pathogen Staphylococcus aureus, MGEs that contain antibiotic resistance genes commonly do not(More)
Antimicrobial peptides serve as a first line of innate immune defense against invading organisms such as bacteria and viruses. In this study, we hypothesized that peptides produced by a normal microbial resident of human skin, Staphylococcus epidermidis, might also act as an antimicrobial shield and contribute to normal defense at the epidermal interface.(More)
  • Gordon Y. C. Cheung, Kevin Rigby, Rong Wang, Shu Y. Queck, Kevin R. Braughton, Adeline R. Whitney +3 others
  • 2010
Staphylococcus epidermidis is a leading nosocomial pathogen. In contrast to its more aggressive relative S. aureus, it causes chronic rather than acute infections. In highly virulent S. aureus, phenol-soluble modulins (PSMs) contribute significantly to immune evasion and aggressive virulence by their strong ability to lyse human neutrophils. Members of the(More)
  • Ching Wen Tseng, Pierre Kyme, Jennifer Low, Miguel A. Rocha, Randa Alsabeh, Loren G. Miller +7 others
  • 2009
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) threatens public health worldwide, and epidemiologic data suggest that the Panton-Valentine Leukocidin (PVL) expressed by most CA-MRSA strains could contribute to severe human infections, particularly in young and immunocompetent hosts. PVL is proposed to induce cytolysis or(More)
  • Saravanan Periasamy, Som S. Chatterjee, Gordon Y. C. Cheung, Michael Otto
  • 2012
P henol-soluble modulins (PSMs) are amphipathic peptides produced by staphylococci that have multiple functions in pathogenesis. For example, they may function as cytotoxins and pro-inflammatory agents. Additionally, in a recent study we demonstrated that Staphylococcus aureus PSMs structure biofilms and cause dissemination during biofilm infection. Based(More)
  • Som S. Chatterjee, Liang Chen, Hwang-Soo Joo, Gordon Y. C. Cheung, Barry N. Kreiswirth, Michael Otto
  • 2011
The phenol-soluble modulin PSM-mec is the only known staphylococcal toxin that is encoded on a mobile antibiotic resistance determinant, namely the staphylococcal cassette chromosome (SCC) element mec encoding resistance to methicillin. Here we show that the psm-mec gene is found frequently among methicillin-resistant Staphylococcus aureus (MRSA) strains of(More)
  • Haitske Graveland, Jaap A. Wagenaar, Hans Heesterbeek, Dik Mevius, Engeline van Duijkeren, Dick Heederik +1 other
  • 2010
INTRODUCTION Recently a specific MRSA sequence type, ST398, emerged in food production animals and farmers. Risk factors for carrying MRSA ST398 in both animals and humans have not been fully evaluated. In this cross-sectional study, we investigated factors associated with MRSA colonization in veal calves and humans working and living on these farms. (More)
The molecular processes underlying epidemic waves of methicillin-resistant Staphylococcus aureus (MRSA) infection are poorly understood(1). Although a major role has been attributed to the acquisition of virulence determinants by horizontal gene transfer(2), there are insufficient epidemiological and functional data supporting that concept. We here report(More)
  • Natalia Malachowa, Adeline R. Whitney, Scott D. Kobayashi, Daniel E. Sturdevant, Adam D. Kennedy, Kevin R. Braughton +5 others
  • 2011
Staphylococcus aureus is a leading cause of bloodstream infections worldwide. In the United States, many of these infections are caused by a strain known as USA300. Although progress has been made, our understanding of the S. aureus molecules that promote survival in human blood and ultimately facilitate metastases is incomplete. To that end, we analyzed(More)
  • Binh An Diep, Amy M. Palazzolo-Ballance, Pierre Tattevin, Li Basuino, Kevin R. Braughton, Adeline R. Whitney +5 others
  • 2008
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains typically carry genes encoding Panton-Valentine leukocidin (PVL). We used wild-type parental and isogenic PVL-deletion (Delta pvl) strains of USA300 (LAC and SF8300) and USA400 (MW2) to test whether PVL alters global gene regulatory networks and contributes to pathogenesis of(More)