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WIN 51711 and WIN 52084 are structurally related, antiviral compounds that inhibit the replication of rhino (common cold) viruses and related picornaviruses. They prevent the pH-mediated uncoating of the viral RNA. The compounds consist of a 3-methylisoxazole group that inserts itself into the hydrophobic interior of the VP1 beta-barrel, a connecting(More)
2'-Deoxy-2'-fluorocytidine (FdC) is a potent inhibitor of the hepatitis C virus RNA replicon in culture, and FdC-5'-triphosphate is an effective inhibitor of the NS5B polymerase. Dynamic profiling of cell growth in an antiviral assay showed that FdC caused cytostasis due to an S-phase arrest. These observations demonstrate that FdC treatment is affecting(More)
  • P Y Lam, P K Jadhav, C J Eyermann, C N Hodge, Y Ru, L T Bacheler +4 others
  • 1994
Mechanistic information and structure-based design methods have been used to design a series of nonpeptide cyclic ureas that are potent inhibitors of human immunodeficiency virus (HIV) protease and HIV replication. A fundamental feature of these inhibitors is the cyclic urea carbonyl oxygen that mimics the hydrogen-bonding features of a key structural water(More)
Let G be a complex semisimple Lie group and τ a complex antilinear involution that commutes with a Cartan involution. If H denotes the connected subgroup of τ-fixed points in G, and K is maximally compact, each H-orbit in G/K can be equipped with a Poisson structure as described by Evens and Lu. We consider sym-plectic leaves of certain such H-orbits with a(More)
This paper introduces a novel system for interactive evaluation and verification of manual assembly processes. The approach utilizes a scalable, interactive augmented floor surface in combination with a tangible tabletop hardware and a material zone planning software. The floor projection hardware is used for true to scale assembly station layout(More)
The real finite section thickness of histologic slices is one of the dominant artefacts in morphometrical studies. Investigations without correction of the section thickness error are not reproducible or comparable. On this basis we measured the real finite section thickness of histologic slices with a nominal section thickness of 2, 4 and 6 microns with a(More)
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