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In this paper, we examine parallel filesystems for shared deployment across multiple Linux clusters running with different hardware architectures and operating systems. Specifically, we deploy PVFS2, GPFS, Lustre, and TerraFS in our test environment containing Intel Xeon, Intel x86-64, and IBM PPC970 systems. We comment on the feature sets of each(More)
INTRODUCTION Uncemented stems in total hip arthroplasty (THA) are used increasingly often because they are believed to offer a reliable long-term fixation. However, periprosthetic bone remodelling has been a worrying issue. A proximal demineralization has been noted in femurs with well-fixed stems, and it has been explained as by-passing of mechanical(More)
Mutagenesis of group B streptococcus (GBS) with TnphoZ, a transposon designed to identify secreted protein genes, identified the gene homologues fhuD and fhuG. The encoded proteins participate in siderophore (hydroxamate)-dependent iron(III) transport in other bacterial species. Sequence analysis of the genome determined that fhuD and fhuG are members of a(More)
While much high-performance computing is performed using massively parallel MPI applications, many workflows execute jobs with a mix of processor counts. At the extreme end of the scale, some workloads consist of large quantities of single-processor jobs. These types of workflows lead to inefficient usage of massively parallel architectures such as the IBM(More)
Remote Direct Memory Access (RDMA) is an effective technology for reducing system load and improving performance. Recently, Ethernet offerings that exploit RDMA technology have become available that can potentially provide a high-performance fabric for MPI communications at lower cost than other competing technologies. The goal of this paper is to evaluate(More)
With the advent of Grid computing technology and the continued improvements to high-performance network infrastructure, computational science in distributed computing environments has become an essential research platform for scientists that require access to distributed computational resources, scientific data archives, or Grid-enabled scientific(More)
The design and procurement of supercomputers may require months, but the construction of a facility to house a supercomputer can extend to years. This paper describes the design and construction of a Top-50 supercomputer system and a fully-customized pre-fabricated facility to house it. The use of a co-design process reduced the time from conception to(More)
In this paper, we examine the performance of two components of the NCAR Community Climate System Model (CCSM) executing on clusters with a variety of microprocessor architectures and interconnects. Specifically, we examine the execution time and scalability of the Community Atmospheric Model (CAM) and the Parallel Ocean Program (POP) on Linux clusters with(More)
The streptococcal C5a peptidase (ScpB) of group B streptococci (GBS) is found in virtually all clinical GBS isolates and is required for mucosal colonization in a neonatal mouse model. ScpB inhibits neutrophil chemotaxis by enzymatically cleaving the complement component C5a. We previously identified a second function of ScpB as a fibronectin (Fn) adhesin(More)
The University of Colorado (CU) and the National Center for Atmospheric Research (NCAR) have been deploying complimentary and federated resources supporting computational science in the Western United States since 2004. This activity has expanded to include other partners in the area, forming the basis for a broader Front Range Computing Consortium (FRCC).(More)