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- Denise Harold, Richard Sesin Abraham, +84 authors Julie Williams
- Nature Genetics
- 2009
The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we conducted a large genome-wide… (More)
- Paul Hollingworth, Denise Harold, +169 authors Julie Williams
- Nature Genetics
- 2011
We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium… (More)
- Pak Sham, Joel S. Bader, Ian Craig, Michael O'Donovan, Michael Owen
- Nature Reviews Genetics
- 2002
DNA pooling is a practical way to reduce the cost of large-scale association studies to identify susceptibility loci for common diseases. Pooling allows allele frequencies in groups of individuals to… (More)
- Patrick F. Sullivan, Mark J. Daly, Michael O'Donovan
- Nature Reviews Genetics
- 2012
Psychiatric disorders are among the most intractable enigmas in medicine. In the past 5 years, there has been unprecedented progress on the genetics of many of these conditions. In this Review, we… (More)
- Andrew Grupe, Richard Sesin Abraham, +24 authors Julie Williams
- Human molecular genetics
- 2007
This study sets out to identify novel susceptibility genes for late-onset Alzheimer's disease (LOAD) in a powerful set of samples from the UK and USA (1808 LOAD cases and 2062 controls). Allele… (More)
- Sagiv Shifman, Martina M Johannesson, +13 authors Ariel Darvasi
- PLoS genetics
- 2008
Sex differences in schizophrenia are well known, but their genetic basis has not been identified. We performed a genome-wide association scan for schizophrenia in an Ashkenazi Jewish population using… (More)
- Stephan Ripke, Naomi R Wray, +113 authors Patrick F. Sullivan
- Molecular Psychiatry
- 2013
Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have met with limited success. We sought to increase statistical power to detect disease loci by conducting a GWAS… (More)
- Benjamin M. Neale, Sarah E. Medland, +51 authors Stan F. Nelson
- Journal of the American Academy of Child and…
- 2010
OBJECTIVE
Although twin and family studies have shown attention-deficit/hyperactivity disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome-wide significant level… (More)
- Avshalom Caspi, Kate Langley, +9 authors Anita Thapar
- Archives of general psychiatry
- 2008
CONTEXT
Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous neurodevelopmental disorder that in some cases is accompanied by antisocial behavior.
OBJECTIVE
To test if variations in… (More)
- Anavaj Sakuntabhai, Victor Ivan Ruiz-Perez, +14 authors Alain Hovnanian
- Nature Genetics
- 1999
Darier disease (DD) is an autosomal-dominant skin disorder characterized by loss of adhesion between epidermal cells (acantholysis) and abnormal keratinization. Recently we constructed a 2.4-Mb,… (More)