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Peroxisome Proliferator-Activated Receptor Alpha Target Genes
TLDR
An overview of the involvement of PPARα in lipid metabolism and other pathways through a detailed analysis of the different known or putative PPAR α target genes is presented. Expand
Nutrigenomics: goals and strategies
TLDR
Applied wisely, nutrigenomics will allow effective dietary-intervention strategies to recover normal homeostasis and to prevent diet-related diseases. Expand
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity.
TLDR
The inflammasome is an important regulator of adipocyte function and insulin sensitivity, and caspase-1 inhibition may represent a novel therapeutic target in clinical conditions associated with obesity and insulin resistance. Expand
Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression.
TLDR
PPARalpha and PPARalpha-signaling are activated in liver by chronic high-fat feeding; PPARgamma may compensate for PPAR Alpha in PPAR alpha null mice on HFD; and Adenoviral overexpression of PPargamma in liver indicated that PPARGamma can up-regulate genes involved in lipo/adipogenesis but also characteristic PPARAlpha targets involved in fatty acid oxidation. Expand
Comprehensive Analysis of PPARα-Dependent Regulation of Hepatic Lipid Metabolism by Expression Profiling
TLDR
In wild-type mice fed a high fat diet, the decrease in hepatic lipids following treatment with the PPAR α agonist Wy14643 was paralleled by significant up-regulation of Pnpla2, Lipe, and Mgll, suggesting that induction of triglyceride hydrolysis may contribute to the anti-steatotic role of PPARα. Expand
The Fasting-induced Adipose Factor/Angiopoietin-like Protein 4 Is Physically Associated with Lipoproteins and Governs Plasma Lipid Levels and Adiposity*
TLDR
The composite data suggest that via physical association with plasma lipoproteins, FIAF acts as a powerful signal from fat and other tissues to prevent fat storage and stimulate fat mobilization. Expand
The Direct Peroxisome Proliferator-activated Receptor Target Fasting-induced Adipose Factor (FIAF/PGAR/ANGPTL4) Is Present in Blood Plasma as a Truncated Protein That Is Increased by Fenofibrate
TLDR
Levels of both truncated and native FIAF showed marked interindividual variation but were not associated with body mass index and were not influenced by prolonged semistarvation, suggesting that FIAF, similar to other adipocytokines such as adiponectin, may partially exert its function via a truncated form. Expand
The G0/G1 switch gene 2 is a novel PPAR target gene.
TLDR
Interestingly, the G0S2 mRNA level was highest in brown and white adipose tissue and was greatly up-regulated during mouse 3T3-L1 and human SGBS (Simpson-Golabi-Behmel syndrome) adipogenesis, indicating that G 0S2 is a novel target gene of PPARs that may be involved in adipocyte differentiation. Expand
Caloric Restriction and Exercise Increase Plasma ANGPTL4 Levels in Humans via Elevated Free Fatty Acids
TLDR
The results show that plasma ANGPTL4 levels are increased by fasting, caloric restriction, and exercise, which is likely mediated by elevated plasma FFAs. Expand
PPARs, Obesity, and Inflammation
TLDR
The role of PPARs in obesity-induced inflammation specifically in adipose tissue, liver, and the vascular wall is addressed, with a growing recognition that obesity represents a state of chronic low-level inflammation. Expand
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