Michael Merzenich

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  • Brennon Dickson, Norman Doidge, Paul Bach-Y-Rita, Aleksandr Luria, Mark Rosenzweig, Michael Merzenich +4 others
  • 2008
delves deeply into the contemporary neuroscience of brain plasticity. Doidge is a psychiatrist and psychoanalyst and works as a researcher at the Columbia University Center for Psychoanalytic Training and Research in New York and as a faculty member in the University of Toronto's Department of Psychiatry. His artistry with words reflects the fact that he is(More)
Serotonin (5-HT) plays a key role in early brain development, and manipulation of 5-HT levels during this period can have lasting neurobiological and behavioral consequences. It is unclear how perinatal exposure to drugs, such as selective serotonin reuptake inhibitors (SSRIs), impacts cortical neural network function and what mechanism(s) may elicit the(More)
Numerous studies have suggested that the brain may encode information in the temporal firing pattern of neurons. However, little is known regarding how information may come to be temporally encoded and about the potential computational advantages of temporal coding. Here, it is shown that local inhibition may underlie the temporal encoding of spatial(More)
In our hypothesis of focal dystonia, attended repetitive behaviors generate aberrant sensory representations. Those aberrant representations interfere with motor control. Abnormal motor control strengthens sensory abnormalities. The positive feedback loop reinforces the dystonic condition. Previous studies of primates with focal hand dystonia have(More)
One of the current challenges to understanding neural information processing in biological systems is to decipher the \code" carried by large populations of neurons acting in parallel. We present an algorithm for automated discovery of stochastic ring patterns in large ensembles of neurons. The algorithm, from the \Helmholtz Machine" family, attempts to(More)
Aging is associated with deficits in the ability to ignore distractions, which has not yet been remediated by any neurotherapeutic approach. Here, in parallel auditory experiments with older rats and humans, we evaluated a targeted cognitive training approach that adaptively manipulated distractor challenge. Training resulted in enhanced discrimination(More)
The brain represents the skin surface as a topographic map in the somatosensory cortex. This map has been shown experimentally to be modifiable in a use-dependent fashion throughout life. We present a neural network simulation of the competitive dynamics underlying this cortical plasticity by detailed analysis of receptive field properties of model neurons(More)
While the understanding of the functional role of different classes of neurons in the awake primary visual cortex has been extensively studied since the time of Hubel and Wiesel (Hubel and Wiesel, 1962), our understanding of the feature selectivity and functional role of neurons in the primary auditory cortex is much farther from complete. Moving bars have(More)