Michael Meier

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This article introduces two theoretical concepts for the emerging field Knowledge Visualization and discusses a new visualization application that was used to communicate a long-term project to various stakeholders in an organization. First, we introduce a theoretical framework and a model for Knowledge Visualization. The framework and the model identify(More)
This article discusses three tools that allow making collaboration and decision-making more effective. It presents insights from working in the “ETH Baugarten Value Lab”, a new research space with five touch displays. First, the article introduces this lab. Then, it introduces two software tools to support communication and group(More)
Mutations in subunits or regulators of cohesin cause a spectrum of disorders in humans known as the 'cohesinopathies'. Cohesinopathies, including the best known example Cornelia de Lange syndrome (CdLS), are characterized by broad spectrum, multifactorial developmental anomalies. Heart defects occur at high frequency and can reach up to 30% in CdLS. The(More)
In this paper, we describe a tool to improve inter-functional communication of project plans by displaying them as a metro map. Our tool automatically lays out plans using a multicriteria system adapted for the application area. Previous studies have shown that displaying project plans using a metro map metaphor as a complementary visualization to Gantt(More)
This paper presents a framework and three case studies on knowledge maps in organizations. In organizations, speed, clarity, and effectiveness are essential for the transfer of knowledge. Today, mainly text is used. This paper illustrates how knowledge maps, a subset of knowledge visualization, help to transfer strategic knowledge in organizations. First,(More)
The burden of malnutrition, including both over- and undernutrition, is a major public health concern. Here we used a zebrafish model of diet-induced obesity to analyze the impact of dietary intake on fertility and the phenotype of the next generation. Over an eight-week period, one group received 60 mg of food each day (60 mg arm), while another received 5(More)
At zygotic genome activation (ZGA), changes in chromatin structure are associated with new transcription immediately following the maternal-to-zygotic transition (MZT). The nuclear architectural proteins, cohesin and CCCTC-binding factor (CTCF), contribute to chromatin structure and gene regulation. We show here that normal cohesin function is important for(More)
Runx1 is a transcription factor essential for definitive hematopoiesis. In all vertebrates, the Runx1 gene is transcribed from two promoters: a proximal promoter (P2), and a distal promoter (P1). We previously found that runx1 expression in a specific hematopoietic cell population in zebrafish embryos depends on cohesin. Here we show that zebrafish runx1 is(More)
The promoter is a key element in gene transcription and regulation. We previously reported that artificial sequences rich in the dinucleotide CpG are sufficient to drive expression in vitro in mammalian cell lines, without requiring canonical binding sites for transcription factor proteins. Here, we report that introducing a promoter organization that(More)
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