Michael Mays

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In this study, we sought to determine whether pertussis toxin (PT), an exotoxin virulence factor produced exclusively by Bordetella pertussis, is important for colonization of the respiratory tract by this pathogen by using a mouse intranasal infection model. By comparing a wild-type Tohama I strain to a mutant strain with an in-frame deletion of the ptx(More)
BACKGROUND Pertussis toxin (PT) is an exotoxin virulence factor produced by Bordetella pertussis, the causative agent of whooping cough. PT consists of an active subunit (S1) that ADP-ribosylates the alpha subunit of several mammalian G proteins, and a B oligomer (S2-S5) that binds glycoconjugate receptors on cells. PT appears to enter cells by endocytosis,(More)
We dedicate this paper (and the rhombus) to Professor Henry Gould on the occasion of his 70th birthday and in appreciation of his work on recurrences such as the rhombus Abstract Pascal's rhombus is a variation of Pascal's triangle in which values are computed as the sum of four terms, rather than two. It is shown that the limiting ratio of the number of(More)
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