Michael Manuel Smith

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Cell blocks prepared from residual tissue fluids and fine-needle aspirations can be useful adjuncts to smears for establishing a more definitive cytopathologic diagnosis. They can be particularly useful for categorization of tumors that otherwise may not be possible from smears themselves. A modified cell block technique using an improvised ethanol formalin(More)
Very few studies have explored the cardiovascular effects of progesterone in premenopausal women. This study aimed to examine the short-term effects of oral progesterone alone, transdermal estrogen alone, and progesterone and estrogen combined on flow-mediated dilation (FMD) in healthy reproductive-aged women. We suppressed endogenous estrogens and(More)
These studies were designed to determine whether or not substantia nigra (SN) neurons project to the mesencephalic locomotor region (MLR). An attempt was made to activate SN neurons antidromically from the same site which induced locomotion on a treadmill following a precollicular-postmammillary transection in the same animal. Less than 10% of posterior SN(More)
OBJECTIVE IA therapy with hyaluronan (HA) is reported to provide symptomatic relief and disease modification in OA. This study assessed the pathological changes in the synovium of an ovine model of OA and evaluated the effects of two HA preparations on this pathology. METHODS Eighteen sheep had bilateral lateral meniscectomy to induce OA. Four months(More)
OBJECTIVES Published scoring methods for quantifying synovitis focus on acute inflammatory parameters, and are unsuitable as outcome measures in experimental surgical models of osteoarthritis (OA). The aim of the present study was to define a modified histopathological scoring system for ovine synovium more suited to the chronic pathology induced by ovine(More)
Increased arterial stiffness is associated with an impairment of ventricular–vascular coupling efficiency and increased risk of cardiovascular mortality. Recently, it has been suggested that an increase in arterial stiffness is associated with resistance exercise training. Therefore, the aims of this study were to compare augmentation index (AIx) and left(More)
Amid the most widely studied NP-hard combinatorial optimization problems, the Probabilistic Traveling Salesman Problem (PTSP), which is an extension of the well-known Traveling Salesman Problem, offers a fundamental basis for analyzing the stochastic impacts in routing problems. In this paper, a new meta-heuristic approach, Genetic Minimum Matrix Search(More)
diet is one modeled after the perceived food consumption of early human ancestors of the Paleolithic Era, consisting of mainly meat, fish, fruit, vegetables, eggs, and nuts. The purpose of this study was to examine the effects of a Paleo diet on blood lipids, including high-density lipoprotein (HDL), low-density lipoprotein (LDL), non-HDL cholesterol,(More)
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