Michael Malone

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Background AZD3514 is a first-in-class, orally bio-available, androgen-dependent and -independent androgen receptor inhibitor and selective androgen-receptor down-regulator (SARD). Methods In study 1 and 2, castration-resistant prostate cancer (CRPC) patients (pts) were initially recruited into a once daily (QD) oral schedule (A). In study 1,(More)
Primary malignancies of the aorta are extremely rare. A review of the literature indicates that 35 documented cases of primary tumors of the aorta have been reported over the past 120 years. The histologic and morphologic characteristics of these lesions may be variable. In this case, progressive claudication of the left leg and buttocks with absent femoral(More)
PURPOSE Deep vein thrombosis (DVT) is a preventable cause of morbidity and mortality in patients who are hospitalized. An important part of the mechanism of DVT prophylaxis with intermittent pneumatic compression (IPC) is reduced venous stasis with increased velocity of venous return. The conventional methods of IPC use low pressure and slow inflation of(More)
Catheter-directed thrombolysis and intraoperative intra-arterial thrombolysis are important adjuncts to how we care for patients with acute arterial and bypass graft occlusions. Of importance is that intra-arterial thrombolysis not to be thought of as a competitor to operative revascularization, but rather as an adjunct to what can be accomplished, which(More)
Persistent sciatic artery (PSA) is an uncommon medical condition that can result in limb loss if it is not recognized or corrected. It is associated with 14% limb loss and 86% formation of aneurysm of the sciatic artery. In this study we describe a patient with bilateral persistent sciatic arteries associated with multiple aneurysms who presented with a(More)
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