Michael M. Lacy

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Ototoxicity is a main dose-limiting factor in the clinical application of aminoglycoside antibiotics. Despite longstanding research efforts, our understanding of the mechanisms underlying aminoglycoside ototoxicity remains limited. Here we report the discovery of a novel stress pathway that contributes to aminoglycoside-induced hair cell degeneration.(More)
We have investigated the membrane remodeling capacity of the N-terminal membrane-binding domain of α-synuclein (α-Syn100). Using fluorescence correlation spectroscopy and vesicle clearance assays, we show that α-Syn100 fully tubulates POPG vesicles, the first demonstration that the amphipathic helix on its own is capable of this effect. We also show that at(More)
  • Brian Lee, Duane S Boning, Winthrop Baylies, Noel Poduje, Pat Hester, Yong Xia +5 others
  • 2001
Nanotopography refers to 10-100 nm surface height variations that exist on a lateral millimeter length scale on unpatterned silicon wafers. Chemical mechanical polishing (CMP) of deposited or grown films (e.g., oxide or nitride) on such wafers can generate undesirable film thinning which can be of substantial concern in shallow trench isolation (STI)(More)
According to the United States Department of Health and Human Services Administration on Aging, more than 14 percent of the US population is 65 or older, a percentage that is predicted to steadily increase over the next several decades. The rapid growth of this segment of the population is not a phenomenon limited to the United States — the global(More)
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