Michael Lynge Pedersen

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BACKGROUND AND PURPOSE Glycogen synthase kinase-3 (GSK-3) affects neuropathological events associated with Alzheimeŕs disease (AD) such as hyperphosphorylation of the protein, tau. GSK-3beta expression, enzyme activity and tau phosphorylated at AD-relevant epitopes are elevated in juvenile rodent brains. Here, we assess five GSK-3beta inhibitors and lithium(More)
OBJECTIVES To estimate the age- and gender-specific consultation rates of patients who availed primary health care service in Greenland and to analyse contact patterns among patients in Nuuk. DESIGN Observational and cross-sectional register study using data captured from the medical records. MATERIALS AND METHODS The number of patients specified by age(More)
OBJECTIVE The aim of this study was to estimate the prevalent use of drugs targeting obstructive lung diseases among adults aged 50 or above in Greenland and to assess the use of spirometry testing among these medication users. STUDY DESIGN Observational cross-sectional study based on reviews of electronic medical records. METHODS The study was(More)
RATIONALE Many antipsychotics cause orthostatic hypotension possibly due to antagonist action on resistance vessel alpha1A-adrenoceptors (alpha1A-AR). OBJECTIVE We have tested this possibility by determining in Wistar rats how the orthostatic hypotensive effect of several antipsychotic drugs compares with their affinity for adrenoceptors in mesenteric(More)
BACKGROUND The suicide rate in Greenland, especially among men, is among the highest in the world. Attempted suicide rates may be high also. However, the rates of attempted suicide are unknown. OBJECTIVE We aimed to estimate the age- and gender-specific incidence of attempted suicide using medicine in Nuuk in 2008-2009. DESIGN An observational(More)
BACKGROUND The prevalence of undiagnosed diabetes mellitus (DM) in Greenland has been reported very high with only 30% of cases diagnosed. In 2010, glycosylated hemoglobin (A1C) was introduced as a diagnostic tool in Greenland. However, the current use of A1c is unknown as well as the current prevalence of diagnosed DM.The aim of this study was firstly to(More)
OBJECTIVES The primary objective was to estimate the prevalence of patients diagnosed with hypertension using the proxy marker of antihypertensive drug therapy in Greenland and to compare the prevalences within the 5 health regions in Greenland. The second objective was to review 2 quality indicators in antihypertensive care. STUDY DESIGN Observational(More)
OBJECTIVES To estimate age- and gender-specific incidence rates among Greenlandic stroke-survivors. STUDY DESIGN The study was performed as a cross-sectional observational study. METHODS All Greenlandic patients admitted to Queen Ingrid's Hospital (QIH) with stroke in 2011 and 2012 were included in the study. Data were obtained from patient files and(More)
OBJECTIVE To estimate the incidence of syphilis from 2010 to 2014 and to assess whether contact tracing has been performed. STUDY DESIGN Observational cross-sectional study. METHOD Data on reported cases were collected from the national register of the chief medical officer in Greenland. Unreported cases were found by searching the electronic medical(More)
Objectives Sexually transmitted infections (STIs), including infections with Neisseria gonorrhoeae (GC), are highly incident in Greenland. Since January 2011, GC testing has been performed on urine with nucleic acid amplification tests (NAATs) by strand displacement amplification (Becton Dickinson ProbeTec). Monitoring of GC antibiotic susceptibility by(More)